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CTRI Number  CTRI/2025/06/089193 [Registered on: 20/06/2025] Trial Registered Prospectively
Last Modified On: 11/06/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda
Other (Specify) 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Efficacy of therapeutic emesis with Ikshvaku drug in Psoriasis  
Scientific Title of Study   A clinical study to evaluate the effectiveness of Vamana Karma with Ikshvaku in Eka-Kushtha 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Rajni Sharma 
Designation  Ph.D Scholar 
Affiliation  SGT University 
Address  SGT University, D-Block, Room No.404, 4th floor, Gurugram, Harayana.

Gurgaon
HARYANA
122505
India 
Phone  7507373663  
Fax    
Email  rajnisharma.oct@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Rajni Sharma 
Designation  Ph.D Scholar 
Affiliation  SGT University 
Address  SGT University, D-Block, Room No.404, 4th floor, Gurugram, Harayana.

Gurgaon
HARYANA
122505
India 
Phone  7507373663  
Fax    
Email  rekha.ayurveda@sgtuniversity.org  
 
Details of Contact Person
Public Query  
Name  Dr Rekha Phull 
Designation  Professor and HOD  
Affiliation  SGT University 
Address  SGT University, D-Block, Room No.404, 4th floor, Gurugram, Harayana.

Gurgaon
HARYANA
122505
India 
Phone  7507373663  
Fax    
Email  rekha.ayurveda@sgtuniversity.org  
 
Source of Monetary or Material Support  
SGT Ayurveda Hospital, Kaliawas, Gurugram, Haryana. 
 
Primary Sponsor  
Name  SGT University 
Address  SGT University, Chandu, Budhera, Gurugram, Haryana, 122505 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Rajni Sharma  SGT Ayurveda Hospital  SGT University, D-Block, Room No.404, 4th floor, Gurugram, Harayana.
Gurgaon
HARYANA 		 7507373663

rajnisharma.oct@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
institutional ethical commiittee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:L500||Allergic urticaria. Ayurveda Condition: EKAKUSHTHAH, (2) ICD-10 Condition:L503||Dermatographic urticaria. Ayurveda Condition: EKAKUSHTHAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure-dIpana , दीपन pachana, ghritapana, vamana (Procedure Reference: charak samhita kalpa sthana chapter 1, Procedure details: deepana pachana followed by ghitapana & vamana)
(1) Medicine Name: Ikshvaku, Reference: kalpasthana , Route: Oral, Dosage Form: Kwatha/Kashaya, Dose: 3(NA), Frequency: od, Duration: 1 Days
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1 Patients who have scored more than 0 for Asvedanam, Mahavastu & Matsyashakalata lakshana in assessment criteria.
2 Patients having signs and symptoms of Eka-kushtha according to Charaka Samhita.
3 Age group from 20 to 60 yrs.
4 Patient of either sex.
5 Vamanarha patients.

 
 
ExclusionCriteria 
Details  • Patients with complications like Cardiac problems, emphysema, carcinoma, etc. will be excluded.
• Pregnant woman and lactating mothers will be excluded.
• The patients above 60yrs and below 18yrs will be excluded.
 
 
Method of Generating Random Sequence   Random Number Table 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Relief in the signs and symptoms of Eka Kushtha like matsyasakalta, aswednam etc.  4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/06/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="1"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

 

In Ayurveda, skin diseases are included under the heading of Kushtha or Kshudra Rogas. Out of them Kshudra Kushtha is the Eka-kushtha which can be correlated up to certain extent with Psoriasis. It is chronic, non-infectious & common skin disease of today’s time. It is a very attention seeking problem approximately 2-3 % (125 million) population of the world suffering from the disease

Eka-kushtha may be characterized as follows

1.       Absence of perspiration (Asvedanam)

2.       Extensive localization (Mahavastu)

3.       It resembles the scales of fish (Matsyashakalata). Eka-kushtha is curable disease but its relapsing nature causes more harassment for the patient. It is correlated to certain extent with Psoriasis.

 NEED AND SIGNIFICANCE:

There are many studies carried out on Vamana Karma by Madanphala and Jeemutaka but there are no studies reported on the use of Ikshvaku as a Vamaka dravya. So unexplored Vamaka dravya should be addressesd. The present study will evaluate the efficacy of Ikshvaku as a Vamaka dravya in Eka-kushtha. 

HYPOTHESIS:

 Proper Vamana karma with Ikshvaku will remove Eka-kushtha.

H0=   Ikshvaku don’t have any effect in Eka- Kushtha

H1=  Ikshvaku has significant effect in Eka-Kushtha.

 AIM

  To study the efficacy of Vamana karma using  Ikshvaku in the patients of Eka-Kushtha.

OBJECTIVES

·         To study the effects of Ikhvaku as Vamakadravya in Eka-kushtha.

·         To study the reduction in the symptoms of Eka-kushtha.

MATERIALS & METHODS

·       Ikshvaku seeds -whole fruit decoction with seed powder decoction(13gm seed powder)

·       Yashtimadhu Kashayam- 3 to 5 litre

·        Madhu- 40-60 gm

·        Saindhav- 10 gm

·        Cows milk- 1.5 lit- 2 lit

·         All these drugs and its raw materials will be purchased from Khari Baoli of Delhi market and the authentication and standardization will be done.

·         Fresh Vamaka Kalpa will be prepared at the time of clinical trial as the Standard Operative Procedure given in Charaka Samhita and under the guidance of guide.


 
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