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CTRI Number  CTRI/2025/07/089964 [Registered on: 02/07/2025] Trial Registered Prospectively
Last Modified On: 01/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Other 
Public Title of Study   Studying Heart Changes in People with Kaphaj Hrudroga Using 2D Echocardiography. 
Scientific Title of Study   A cross sectional study of structural involvement and changes in heart in patients of kaphaj hrudroga using 2D echocardiography. 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Pravin Keshao Girhe 
Designation  Pg scholar 
Affiliation  PDEAS College of Ayurveda and research centre Pune 
Address  PDEAS College of Ayurveda and research centre Sharir Rachana Department Ground floor Nigdi Pune Maharashtra
PDEAS College of Ayurveda and research centre sharir Rachana Department ground floor Nigdi Pune Maharashtra 411044
Pune
MAHARASHTRA
411044
India 
Phone  8378917280  
Fax    
Email  pravingirhe5@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Madhuri Mahadar 
Designation  Associate Professor  
Affiliation  PDEAS College of Ayurveda and research centre  
Address  PDEAS College of Ayurveda and research centre sharir Rachana department ground floor Nigdi Pune Maharashtra

Pune
MAHARASHTRA
411044
India 
Phone  9822002667  
Fax    
Email  drmadhuri75@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Madhuri Mahadar 
Designation  Associate Professor  
Affiliation  PDEAS College of Ayurveda and research centre  
Address  PDEAS College of Ayurveda and research centre sharir Rachana department ground floor Nigdi Pune Maharashtra

Pune
MAHARASHTRA
411044
India 
Phone  9822002667  
Fax    
Email  drmadhuri75@gmail.com  
 
Source of Monetary or Material Support  
PDEAS College of Ayurved and research centre Rachana sharir department ground floor nigdi Pune Maharashtra 411044 
 
Primary Sponsor  
Name  PDEAS College of Ayurved and research centre 
Address  PDEAS College of Ayurved and research centre Rachana sharir department ground floor nigdi Pune Maharashtra 411044 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
Nil  Nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Pravin Keshao Girhe  Ayurved Rugnalaya and sterling and multispeciality hospital  Ayurved Rugnalaya and sterling and multispeciality hospital nigdi pradhikaran pune
Pune
MAHARASHTRA 
8378917280

pravingirhe5@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Chairperson Ethics Committee College of Ayurved And Research Centre Akurdi Pune  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:I509||Heart failure, unspecified. Ayurveda Condition: HRUDROGAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
Intervention  Nil  Nil 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  35.00 Year(s)
Age To  70.00 Year(s)
Gender  Both 
Details  Prior diagnosed patients of kaphaj hrudroga who have recent reports of 2D Echocardiography 
 
ExclusionCriteria 
Details  1. Patient who is suffering from Congenital heart disease.
2) Patient who have undergone coronary artery bypass graft.
3) Patient who have undergone percutaneous transluminal coronary angioplasty, valvular replacement.
4) Known cases of HIV, TB. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To find out structural involvements and changes in Heart in patients of Kaphaj Hrudroga using 2D Echocardiography. 
 
Secondary Outcome  
Outcome  TimePoints 
Nil  Nil 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   16/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Kaphaj Hrudroga is a type of heart disease described in Ayurveda, caused primarily by the aggravation of Kapha dosha. It manifests with a distinct set of symptoms that reflect the heavy, sticky, and cold qualities of Kapha. Patients often report a feeling of stiffness and heaviness in the region of the heart, which is a hallmark of Kapha dominance. There is also a peculiar sensation as if the heart is wrapped in a wet cloth, indicating the damp and constrictive influence of aggravated Kapha on the heart’s function.


Other characteristic symptoms include excessive salivation, which is a sign of increased Kapha in the oral cavity and digestive tract. Mild fever, persistent cough, and drowsiness or lethargy are commonly present, reflecting systemic Kapha imbalance. These symptoms suggest impaired circulation, reduced metabolic fire (Agni), and congestion in the cardiac and respiratory pathways.


From an Ayurvedic perspective, Kaphaj Hrudroga is not merely a structural issue but a functional disorder of the doshas affecting the Rasavaha and Pranavaha Srotas. Early identification and appropriate treatment aimed at pacifying Kapha—through diet, lifestyle, and herbal remedies—are essential to prevent progression and maintain cardiac health.

 
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