Background: Stress, anxiety, and depression are more common mental health issues that significantly affect individuals’ quality of life.  Although there are allopathic treatments for stress, they are often associated with adverse side effects and limited multi-targeted action. In contrast, Ayurvedic herbal remedies, known for their safety and holistic therapeutic effects, are gaining popularity Among them, Yashtimadhu, recognized for its multi-targeted action, particularly on the Manovaha Strotas, has demonstrated neuropharmacological properties, including nootropic, antidepressant, antistress, and anxiolytic effects. Ashwagandha is a well-researched adaptogen that is used extensively for its ability to improve mood and reduce stress. However, there is limited evidence comparing their effectiveness in stress management, particularly in the context of the Depression Anxiety Stress Scale (DASS-21).

Objective: This randomized controlled trial aimed to evaluate and compare the efficacy of Yashtimadhu and Ashwagandha in managing stress, using the

Depression Anxiety Stress Scale (DASS-21) as a primary assessment tool.

Methods: Total 82 participants experiencing stress will be randomly assigned to two groups: Yashtimadhu and Ashwagandha. The trial will have a duration of 3 weeks, with dose of 5gm Churna BD administered according to standard Ayurvedic recommendations. Pre- and post-treatment assessments using the DASS-21 scale will be conducted to measure the levels of depression, anxiety, and stress. The PSS Scale is also used to assess stress.

Results: The results of this study will potentially influence clinical practices and highlight the role of traditional herbal remedies in contemporary stress management strategies.

Conclusion: The final conclusion will be determined after the completion of the randomized controlled trial, which will assess the comparative efficacy of Yashtimadhu and Ashwagandha in the management of stress.

Keywords: Stress, Yashtimadhu, Ashwagandha,  DASS-21, mental health, Ayurveda.