Acharya Sushruta defined Vrana as Gatra Vichoornana, which causes destruction and discoloration of body tissue.¹ Dushta Vrana Lakshanas are Krishna, Rakta, Peeta, Shukla Varna, Putimamsa, Puyasrava, Atyartavedana, Dushtashonitasrava, Daha, Paka, Raga, Kandu, Shopha and Dheerghakaleena².  Dushta Vrana can be correlated to non healing ulcer in allied science.

         Ulcer is a break in the continuity of the covering epithelium, either skin or mucous membrane due to molecular death. Non healing ulcers are characterized by pain, discharge, itching, burning sensation and foul smell. Non healing ulcers include nonspecific ulcers like Traumatic ulcer, Arterial ulcer, Venous ulcer, Trophic ulcer, Infective ulcer, Diabetic ulcer and other.³ An ulcer is a major health problem and it affects nearly 6 million population worldwide. In India it is reported as 4.5 per 1000 population, the incidence of chronic ulcers is expected to increase as the population age increase.⁴

         In modern science ulcer is managed by debridement, ulcer cleaning and dressing. Desloughing is done either mechanically or chemically. Mechanically by debridement. Hydrogen peroxide which releases nascent oxygen is used as chemical agent. Ulcer cleaning and dressing is done daily or twice daily or once in 2-3 days depending on the type of ulcer and type of dressing used.³

         Acharya Sushruta has told various Shodana measures like Sharirika Shodana by Vamana, Virechana and Sthanika Shodana by Kashaya, Kalka, and Avachurana, etc. Lepa karma is one among Shashtiupakrama in which drugs of herbal, herbo-mineral or animal origin are used for Vrana Lepana. Lepa karma is an integral part of Shashtiupakrama which ensures the protection against the microbes and it act as Vranashodana by reducing Vedana and Srava.⁵

          Acharya Chakradatta in the context of Bhagandara Chikitsa explained Tilaabhayadi lepa for Bhagandara and Dushtavrana. It contains drugs like Tila, Abhaya, Lodra, Nimba, Haridra, Daruharidra, Vacha, Kusta, Gruhadooma which possess Shodhana properties.⁶ Acharya Sushruta has mentioned about Nimbadi kalka lepa under Dvivruniya Chikitsa for the Vrana Shodhana which contains drugs like Nimba, Tila and Madhu.⁷

               Here an attempt is made to evaluate and compare the Shodhana effect of Tilaabhayadi Lepa and Nimbadi kalka Lepa in Dushtavrana with special reference to Non healing ulcer.