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CTRI Number  CTRI/2025/02/080919 [Registered on: 19/02/2025] Trial Registered Prospectively
Last Modified On: 10/02/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   Homoeopathic management of rhinosinusitis.  
Scientific Title of Study   Utility of Repertory of Herings Guiding Symptoms of Our Materia Medica By Calvin B.Knerr In The Treatment OF Rhinosinusitis. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Khadijah arshad 
Designation  Postgraduate junior resident 
Affiliation  State national homoeopathic medical college and hospital  
Address  Department of Homoeopathic Repertory and Case-taking State National Homoeopathic Medical College and Hospital,1- Viraj Khand, Gomtinagar Lucknow

Lucknow
UTTAR PRADESH
226010
India 
Phone  7355740039  
Fax    
Email  khadijaharshad193@Gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Sutapa Nandi 
Designation  Reader 
Affiliation  State National Homoeopathic Medical College and Hospital, 1- Viraj Khand, Gomti Nagar Lucknow  
Address  Department of Homoeopathic Repertory and Case-taking State National Homoeopathic Medical College and Hospital, 1- Viraj Khand, Gomti Nagar Lucknow

Lucknow
UTTAR PRADESH
226010
India 
Phone  6351407744  
Fax    
Email  drnandisutapa@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Khadijah Arshad 
Designation  Postgraduate junior resident  
Affiliation  State National Homoeopathic Medical College and Hospital,1-Viraj Khand ,Gomti Nagar ,Lucknow  
Address  Department of Homoeopathic Repertory and Case-taking State National Homoeopathic Medical College and Hospital, 1- Viraj Khand, Gomti Nagar Lucknow

Lucknow
UTTAR PRADESH
226010
India 
Phone  7355740039  
Fax    
Email  khadijaharshad193@gmail.com  
 
Source of Monetary or Material Support  
State National Homoeopathic Medical College and Hospital, 1-Viraj Khand Gomti Nagar, Lucknow 
 
Primary Sponsor  
Name  Dr Khadijah Arshad 
Address  Department of Homoeopathic Repertory and Case-taking, State National Homoeopathic Medical College and Hospital, 1-Viraj Khand Gomti Nagar, Lucknow ,Uttar Pradesh -226010  
Type of Sponsor  Other [SELF] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
DR Khadijah Arshad  State National Homoeopathic Medical College And Hospital  OPD No-7,Department of Homoeopathic Repertory And Case Taking, State National Homoeopathic Medical College And Hospital,1-Viraj Khand, Gomtinagar Lucknow-226010 UP,India. Lucknow UTTAR PRADESH
Lucknow
UTTAR PRADESH 		 7355740039

khadijaharshad193@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
The Institutional Ethical Committee State National Homoeopathic Medical College And Hospital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: J329||Chronic sinusitis, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Individualize homoeopathic Medicine.   Intervention- The individualized homoeopathic medicine will be selected according to the totality of symptoms. Dosage- Medicine will be given in varying potencies of decimal/ centesimal scales as identified from detailed case taking.Each dose shall consist of cane sugar medicated with single medicine. Route-Medicine will be administered via oral route. Dosage and repetition will depend upon the individual requirement of the cases as per the guidelines from organon of medicine. The patient will be called for follow up after every 15 days and final assessment will be done after 6 months. At every follow up after reexamining the case it will be decided whether the patient will receive a dose of individualized homoeopathic medicine or placebo. 
Comparator Agent  Nil  Nil 
 
Inclusion Criteria  
Age From  1.00 Day(s)
Age To  99.00 Year(s)
Gender  Both 
Details  1)Patient of all age group.
2)Both the sexes will be considered
3)Diagnostic criteria are mainly on clinical presentation and X-ray PNS will be done when required.
4)Those who agree to give consent to participate in the study.
5)Those who are willing to have regular follow up visits

 
 
ExclusionCriteria 
Details  1)Patients with complications of other autoimmune diseases.
2)Patients with Immunocompromised disease
3)Mentally retarded patients
4)Patients with congenital defect.
5)Rhinosinusitis presenting with complications like orbital abscess, mucopyocele, oedema of eyelids, meningitis.
6)Patients with chronic respiratory condition like severe asthma.
7)Paranasal sinus and nose surgery.
8)Pregnant and lactating women.
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
To compare the Rhinosinusitis SNOT-22 at baseline and after 6 months of treatment to know the utility of individualized homoeopathic medicine.  12weeks, 24 weeks. 
 
Secondary Outcome  
Outcome  TimePoints 
To compare the X-ray results at baseline and after 3
months of treatment to know the utility of individualized
homoeopathic medicine.  		 4 weeks, 12
weeks  
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   24/02/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   This is an open label, single arm, prospective, interventional study which aims to assess the utility of homoeopathic medicine in the treatment of Rhinosinusitis with the help of Hering’s guiding symptoms of our materia medica by Calvin B. Knerr repertory. Individualized homoeopathic medicine will be prescribed in decimal/ centesimal scale after detailed case taking and repertorization. Rhinosinusitis is a group of disorders characterized by inflammation of the mucosa of the nose and paranasal sinuses. Prevalence rate of chronic rhinosinusitis range from 1% to 12% worldwide. . 1 in 8 Indians is hit by chronic sinusitis. Among respiratory infections, rhinosinusitis is one of the most common illnesses that affects a high proportion of the population. Conventional medicines treats rhinosinusitis with the help of antibiotics, steroids, antihistamines for its relief. The overuse of nasal decongestants can also lead to a condition called rebound congestion in which the person has prolonged stuffiness and nose blockage. Homoeopathic remedies can offer gentle and safe treatment for patients suffering from Rhinosinusitis.  Homoeopathy treats the person as a whole. This includes a detailed medical history of the patient, family and causative factors. Any underlying predisposing factor and susceptibility is also considered.
Therefore, the present study is undertaken to explore how individualized homoeopathic medicine selected on the basis of Repertory Of HERING GUIDING’S SYMPTOMS OF OUR MATERIA MEDICA BY CALVIN B. KNERR  useful in the treatment of Rhinosinusitis .Individualized homoeopathic medicine has  shown  very good results .However ,research studies to further elaborate as well as consolidate  our knowledge is still lacking. There  has been a limited research on Repertory Of HERING’S GUIDING SYMPTOMS OF OUR MATERIA MEDICA BY CALVIN B.KNERR in the treatment of rhinosinusitis. Therefore, intend to undertake this study to research in this particular domain.

  
 
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