This study is randomized double blind, interventional pilot study with sample size 30 patients having 15 patients in each group.

Topical O² therapy is added from 1^st post-operative day. The size of the wound would be assessed on first day and daily. On first post-operative dressing i.e., after 24 hours of surgery the dressing protocol will be initiated.

For dressing, the clinical investigator will be given coded drug filled syringe as per the sequential allocation of coded syringe to add on standard dressing protocol. Syringe will be filled either with papaverine or normal saline as per randomization sequence. Patient has been given normal saline or papaverine will not be known to any person who is doing dressing or collecting the wound assessment data.

Dressing protocol:

1. The wound will be clean with normal saline and mopped with sterile gauze.

2. Either interventional drug i.e. Papaverine injection in concentration of 30mg/ml or Normal saline as placebo will be applied as 1ml per 2-2.5 sq. cm of wound area.

3. It will be applied as topical spray on the wound with the help of 24 G blunt needle and syringe. 

4. Wound will be covered with sterile gauze and standard dressing covering.

Next dressing will be done after 24 hours and daily up to 30 days or till healthy granulation occurs with documentation of wound healing parameters in terms of –

1. Size of wound

2. Quality of granulation – pale or pink or red

3. Exudates – yes or no, If yes - serous or pus

4. Surrounding skin – edema present or not

Wound will be observed for healthy granulation for 30 days. A day when healthy granulation occurs will be noted. During 30 days if healthy granulation occurs wound is prepared for skin grafting or healed by secondary intention.