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CTRI Number  CTRI/2024/12/078653 [Registered on: 27/12/2024] Trial Registered Prospectively
Last Modified On: 24/12/2024
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   How Kents Repertory Helps Treat Kidney Stones with Homoeopathy 
Scientific Title of Study   Utility of Kents Repertory in cases of Renal stone 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Fenil Jagdishkumar Miyani 
Designation  M.D. Scholar part - 2  
Affiliation  C D Pachchigar College Of Homoeopathic Medicine And Hospital  
Address  Department Of Case Taking And Repertory Division Of MD 2nd floor CD Pachchigar College of Homoeopathic Medicine and Hospital Surat Gujarat

Surat
GUJARAT
395001
India 
Phone  8160181397  
Fax    
Email  fenilmiyani000@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Dhaivat Upadhyay 
Designation  Associate Professor Department Of Case Taking And Repertory 
Affiliation  C D Pachchigar College Of Homoeopathic Medicine And Hospital  
Address  Department Of Case Taking And Repertory Division Of MD 2nd floor CD Pachchigar College of Homoeopathic Medicine and Hospital Surat Gujarat

Surat
GUJARAT
395001
India 
Phone  9033764079  
Fax    
Email  udhaivat@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Dhaivat Upadhyay 
Designation  Associate Professor Department Of Case Taking And Repertory 
Affiliation  C D Pachchigar College Of Homoeopathic Medicine And Hospital  
Address  Department Of Case Taking And Repertory Division Of MD 2nd floor CD Pachchigar College of Homoeopathic Medicine and Hospital Surat Gujarat

Surat
GUJARAT
395001
India 
Phone  9033764079  
Fax    
Email  udhaivat@gmail.com  
 
Source of Monetary or Material Support  
Department Of Case Taking And Repertory Division Of MD 2nd floor CD Pachchigar College of Homoeopathic Medicine and Hospital Surat 395001 Gujarat 
 
Primary Sponsor  
Name  C D Pachchigar college of homoeopathic medicine and Hospital 
Address  Department Of Case Taking And Repertory Division Of MD 2nd floor CD Pachchigar College of Homoeopathic Medicine and Hospital Surat 395001 Gujarat 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Fenil Jagdishkumar Miyani  C D Pachchigar College Of Homoeopathic Medicine And Hospital   Department Of Case Taking And Repertory Division Of MD 2nd floor CD Pachchigar College of Homoeopathic Medicine and Hospital Surat 395001 Gujarat
Surat
GUJARAT 
8160181397

fenilmiyani000@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee of C.D. Pachchigar College of Homoeopathic Medicine And Hopsital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: N00-N99||Diseases of the genitourinary system,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Homoeopathic Medicine   Homoeopathic Medicine As Per Requirement Of Case Through Sublingual mode of Administration within time duration of 9 months  
Comparator Agent  NIL  NIL 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Renal stone size less than 12mm. 
 
ExclusionCriteria 
Details  Renal stone size more than 12mm.
patient come with complication like pyelonephritis, hydronephrosis, calculous anuria, chronic renal failure, scarring, abscess and any other life threatening complication.
patient with any pathological disease, critically ill cases which required hospitalization. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To remove Symptoms Of Patients   Removal Of Symptoms Of Renal Stone Depends On The Condition Of The Patients Probably 25 To 30 Days 
 
Secondary Outcome  
Outcome  TimePoints 
To Relief The Patient From Renal Stone And Also Relieving From Recurring Tendency Of Renal Stone   To Improve The Pain of patients within 2 months & after that will assessed recurrency of Renal Stone episode within 9 months. 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   04/01/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  



BRIEF  RESUME  OF  INTENDED  WORK:


NEED  FOR  STUDY:

In present times, many people are having unhealthy lifestyle such as inappropriate diets, sedentary habits and inadequate hydration, this type of lifestyle leads to various health issues, including vitamin deficiency, weight gain and other medical conditions. Among these, renal stones are very common condition. National health and Nutrition Examination Survey data indicate that up to 19% of men and 9% of women will develop at least one stone during their lifetime.

 

Depending on the size of renal stone, some are treated with medication, while others require surgery. Some individuals are afraid to the surgical process, and simultaneously, surgical treatment is also very expensive. In India, many people do not have good socio-economic conditions, so they cannot afford surgery. Those who are hesitant about surgical interventions, may choose homeopathy as an alternative. Homeopathic treatment does not require any surgery in cases of renal stone and it is more affordable compared to surgery.

 

In case of recurrent occurrence, renal stones are not easily removed by cesarean section or lithotripsy. Homeopathy not only cure the disease but also prevent their recurrence.

 

 


REVIEW  OF  LITERATURE:

 

INTRODUCTION

 

The term ‘nephrolithiasis’ is derived from the Greek words ‘Nephros’ which means ‘kidney’ and ‘Lithos’ which means ‘stone’. Nephrolithiasis is common worldwide; this is the third commonest disorder of the urinary tract after urinary tract infection and prostatic hyperplasia. (1)

  

EPIDEMIOLOGY

 

In India, maximum prevalence occurs in Jammu and Kashmir, Punjab, Haryana, Delhi, Rajasthan, Madhya Pradesh and Gujarat. Peak age is 20 to 30years. Recurrence is common; it is 15% at one year, 30 to 40% at 5 years and 50% at 10 years. (1)

 

PATHOGENESIS

 

Normal urine contains both solvents and solutes; imbalance of their relative concentrations results in precipitation of solutes leading to pathological crystallisation which occurs in three stages: stage 1 “under saturation” when

 

 

crystals remain dissolved; stage 2 “saturation” in which urine is saturated with crystals; stage 3 “super saturation” when urine becomes oversaturated with crystals. ‘Nucleation’ is an important initial step, followed by crystal aggregation and stone formation. (1)

 

RISK FACTORS

 

1)Dietary factors that are associated with an increased risk of nephrolithiasis include animal protein, oxalate, sodium, sucrose, and fructose. (2)

2)Higher intake of supplemental calcium. (2)

3)Higher intake of animal protein. (2)

4)Intake of vitamin c supplements. (2)

5)Decreased urine output. (2)

6)Urinary stasis. (3)

7)Deficiency of vitamin A. (3)

8)Renal infection. (3)

 

TYPES OF RENAL STONES 

 

1)Oxalate stone :- It is most common type of renal stones and accounts for 70% of all renal stones. Irregular, sharp projection may lead to haematuria,

Radioopaque. (3)

2)Phosphate stone :- They are form in alkaline urine. Soft, gray-white. They are large and fill most of collecting system, forming “stag-horn stone”.

Radiopaque. (3)

3)Uric acid and Urate stone :- They are form in acidic urine. Hard, smooth, multiple and yellow in colour. Radiolucent. (3) 

4)Cystine stone :- They are form in acidic urine. Hard, multiple. Radiopaque.

(3)

5)Xanthine stone :- They are smooth, brick red in colour. Radiolucent. (3)

 

                     

CLINICAL FEATURES

 

1)Large staghorn stones are usually asymptomatic. (3)

2)Haematuria. (3)

3)Pain felt at renal angle. (3)

4)Pyuria. (3)

5)Common presentation is renal or ureteric colic; acute loin pain radiating to the groin with nausea and vomiting. (1)

6)Stone moving down the ureter causes intermittent ureteric obstruction with acute colicky pain. (1)

7)Urgency, frequency, strangury occur with stone at ureter ovesical junction.

(1)

8)Presence of fever indicates the infection. (1)

 

 

 

 

INVESTIGATION 

 

1)Urine examination (3)

2)Blood examination (3)

3)Renal function test (3)

4)Plain X-ray (3)

5)Ultrasonography (3)

6)CT Scan (3)

 

Homeopathy is a system of alternative medicine that was developed in the late

18th century by Samuel Hahnemann. It is based on the principle of “like cures like”.

 

Clinical practice in homeopathic system of medicine is based upon the integration of Homeopathic Materia Medica, Organon of Medicine & Repertory.

Each of the discipline has it’s own importance but at the same time they are so intimately related to each other that it become difficult to practice homeopathy if any one of these three discipline is not understand properly. Amongst these three, Repertory is an importance tool to find the similimum, each repertory has its own artistic way of presentation, which enables the physician to get best result if used properly by understanding that repertory. (4)

 

KENT’S REPERTORY

 

Repertory of Homeopathic Materia Medica was published by Dr. J.T. Kent in 1897. Kent’s repertory is based on the philosophy of deductive logic that is from GENERAL TO PARTICULAR. (5) (4)

 

TYPOGRAPHY

 

BOLD LETTR

3 marks 

First grade

Italic letter

2 marks

Second grade

Roman letter

1 marks

Third grade

(5) (4)

 

Total no. of chapters- 37 chapters. (5) (4)

It starts with MIND chapter and ends with GENERALITIES chapter. (5) (4)

 

Total no. of medicine- 648 medicines. (5) (4)

 

ARRANGEMENT OF RUBRICS

 

All rubrics are arranged alphabetically in all the chapters. Rubrics are arranged from general to particulars. (5) (4)

 

 

 

Rubric starts with a general symptom or a state with a list of large group of medicines. This is followed by side, time, modality and extension. (5) (4)

 

Side: whenever rubric can be divided into side, general rubric is followed immediately by side, firstly right side than left side. (5) (4)

 

Time: Here also Kent follows logic of general to particulars.            Day time   

Morning

Forenoon

Noon

Afternoon

Evening

Twilight

Night Midnight

After midnight (5) (4)

    

Modalities: they are arranged as follows:

            Ailments from             Alternating with

            Modifying factors, aggravation, amelioration. (5) (4)

 

Extension: this is the last subrubric (5) (4)

 

 


 

 

 

 

 

 

OBJECTIVE  OF  THE  STUDY:

 

•        To study the utility of “Repertory of homeopathic material medica by Dr. J.T. Kent” in management of cases of renal stones.

 

•        To find utility of homeopathic medicines in cases of renal stone with the help of “Repertory of homeopathic material medica by Dr. J.T. Kent.”

 

 

 

 

 

 

 

 

 

 

 

 


MATERIAL  AND  METHODS:


SOURCES  OF  DATA:

 

PROJECT SITE – OPD & IPD of C. D. Pachchigar College of Homoeopathic Medicine & Hospital; Near Navjivan Circle, Udhana Magdalla Road, Surat. 395001

 


MATERIALS:

1.     Case performa prepared for C.D. Pachchigar General Hospital O.P.D.

2.     Kent’s repertory. 

3.     Homoeopathic computerized software: Zomeo software version 13.8.0

4.     Repertorization sheet.

5.     Book of organon of medicine, philosophy, material medica, repertory, all homoeopathic books & literature related to my topic, software & soft or hard research material.

 


METHOD  OF  COLLECTION  OF  DATA:

1.     Study design – Prospective Analytical study

2.     Study population – 100 cases of renal stone treated with help of Kent’s repertory.

3.     Sample size – 30 cases.

4.     Sampling techniques-simple randomization. 

5.     Selection criteria. Inclusion criteria:

 

1.     Patient’s age between 20 to 60 years, in both sexes.

2.     Renal stone size less than 12 mm.

 

Exclusion criteria:

 

1.     Patient’s age less than 20 years and more than 60 years.

2.     Renal stone size more than 12mm.

3.     Patient comes with complication like pyelonephritis, hydronephrosis, calculous anuria, malignancy, chronic renal failure, scarring, abscess and any other life threatening complication.

4.     Patient with any pathological disease, critically ill cases which required hospitalization.

 

 

 

•        Patient is selected on basis of inclusion & exclusion criteria, history & clinical finding.

•        Case taking will be done according to guidelines mentioned by Dr. Hahnemann in Aphorisms 83-104. 

•        After proper analysis and evaluation of symptoms, totality of symptoms will be formed.

•        Repertorization will be done by using Kent’s Repertory from zomeo software version 13.8.0.

•        Totality formation will be done as per the instructions given by Dr. Hahnemann in organon of medicine.

•        Investigations for diagnosis of the disease will be done as per the requirement of the case. 

•        The remedies will be used in various potency as per the requirement of the case.

•        Remedies will be administered as per guidelines given by Dr. Hahnemann in organon of medicine.

•        The remedies will be repeated as per the requirement of the case, on the basis of teachings by Dr. Hahnemann in Organon of medicine.

•        Homoeopathic remedies will be dispensed from C.D. PACHCHIGAR college & hospital homoeopathic pharmacy as per the guidelines of master Hahnemann advised in organon of medicine.

 

Response was analysed as per following criteria’s:

 

1.     Significant Improvement: disappearance of all sign and symptoms with no relapse for 3 months.

 

2.     Improvement: decreased in intensity and/or frequency of presenting complaints with feeling of well being.

 

3.     No improvement: neither increase nor decrease in symptoms of the patient or worse condition of patient.

 


DOES  THE  STUDY 

REQUIRING ANY 

INVESTIGATION  TO  BE

CONDUCTED  ON  PATIENTS  OR OTHER 

HUMANS  OR  ANIMALS?

As per requirement of the case

 


 

HAS  ETHICAL 

CLEARENCE BEEN  OBTAINED  FROM  YOUR INSTITUTE?

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

YES

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


BIBLIOGRAPHY:

 

 

 

1.    Munjal YP. API Textbook of Medicine. Ninth ed. Mumbai: Association of Physicians of India; 2012.

2.    Harrison TR. Harrison’s Principles of Internal Medicine. Twenty first ed. New York: Mcgraw-Hill Medical; 2022.

3.    Naseem A. A Concise Textbook of Surgery. 2nd ed. Gorakhpur: Pulse Publication; 2014.

4.    Tiwari SK. Essentials of Repertorization. 5th ed.: B Jain Pub Pvt Limited; 2012.

5.    Mohanty DN. Evolution/Unfolding of Homeopathic Repertories. 1st ed. New Delhi: Indian Books & Periodicals Publishers; 2005.

6.    Kent JT. Repertory of the Homoeopathic Materia Medica. 6th ed. Kent CL, editor.: B Jain Publishers; 2002.

               

 

 

 

 


 
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