Ageing is a universal process that began with the origin of life. It is defined as the process of growing old, damage to cells, tissues and organs with the passage of time. It is a complex, systemic physiological process characterized by progressive degradation, loss of function, and reduced repair capacity of tissues, cells, organ and make us more susceptible to death. Chronological aging is an irreversible process but the factors causing biological aging can be controlled. We have chosen the drugs of Vayasthapan mahakashaya as mentioned in Charaka Samhita Sutrasthan chapter 4. In classics, it is mentioned that Vayasthapana drugs improves the quality of life, memory, youthfulness and brightness etc. It prevents ill health and block geriatric symptoms. This study is designed to identify the effect of Compund drugs from Vayasthapana mahakashaya to improve the sign and symptoms of Premature Ageing. A clinical study will be conducted to see the efficacy of Vayasthapana Compound churna in improving the signs and symptoms of Akalaja Jara (Premature Ageing). At first, all participants will be screened to check their eligibility for the study. A total of 60 clinically diagnosed patients will be enrolled in this study after taking informed written consent. After that, the first assessment will be done before drug administration with a validated questionnaire and grading will be done according to the signs and symptoms of the patients. Then the drug therapy will be started and the total duration will be 90 days. Three follow ups will be done each after 30 days. The last assessment will be done on the 90th day and the grading will be given again to see the changes in the signs and symptoms of Akalaja Jara . Signatures on informed consent and patient information sheets will be taken on hard copy, and all other relevant data for the study will be collected. After the collection of all the relevant data, the analysis of the data will be done.