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CTRI Number  CTRI/2025/01/079302 [Registered on: 23/01/2025] Trial Registered Prospectively
Last Modified On: 20/01/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Multiple Arm Trial 
Public Title of Study   How Different Types of Exercise Help People with Knee Pain Improve Movement and Reduce Discomfort 
Scientific Title of Study   Effectiveness of Open and Closed Kinetic Chain Exercises on Quadriceps Muscle Thickness, Pain and Functional Performance in Patellofemoral Pain Syndrome among Recreational Players 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Buvanesh Annadurai 
Designation  Assistant Professor 
Affiliation  Saveetha Institute of Medical and Technical Sciences 
Address  5th Floor,A5-Department of Sports and Manual therapy, Saveetha College of Physiotherapy, Saveetha Institute of Madical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai.

Chennai
TAMIL NADU
602105
India 
Phone  8754123645  
Fax    
Email  buvanesh21896@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Buvanesh Annadurai 
Designation  Assistant Professor 
Affiliation  Saveetha Institute of Medical and Technical Sciences 
Address  5th Floor,A5-Department of Sports and Manual therapy, Saveetha College of Physiotherapy, Saveetha Institute of Madical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai.

Chennai
TAMIL NADU
602105
India 
Phone  8754123645  
Fax    
Email  buvanesh21896@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Buvanesh Annadurai 
Designation  Assistant Professor 
Affiliation  Saveetha Institute of Medical and Technical Sciences 
Address  5th Floor,A5-Department of Sports and Manual therapy, Saveetha College of Physiotherapy, Saveetha Institute of Madical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai.

Chennai
TAMIL NADU
602105
India 
Phone  8754123645  
Fax    
Email  buvanesh21896@gmail.com  
 
Source of Monetary or Material Support  
Saveetha College of Physiotherapy, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai Tamilnadu India 602105 
 
Primary Sponsor  
Name  Buvanesh Annadurai 
Address  5th Floor,A5-Department of Sports and Manual therapy, Saveetha College of Physiotherapy, Saveetha Institute of Madical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai, Tamilnadu, India. 602105 
Type of Sponsor  Other [Self Funded] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Vinodhkumar Ramalingam  Saveetha Medical College and Hospital (SMCH)  Room No.105, 1st Floor, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Nagar, Thandalam, 602105
Chennai
TAMIL NADU 
8760563032

vinodhkumar.scpt@saveetha.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Saveetha Medical College and Hospital Institutional Ethics Committee (SMCH-IEC)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M222||Patellofemoral disorders,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Closed Kinetic Chain Exercices  Double or single one-third knee bend, Stationary biking, Step up and down exercise, Lunges, Progressive jumping exercises on a mini trampoline along with Therapeutic Ultrasound and McConnell Taping - 5 weeks 
Comparator Agent  Conventional Therapy  Conventional Therapy along with Therapeutic Ultrasound and McConnell Taping - 5 weeks 
Intervention  Open Kinetic Chain Exercices  Maximal static quadriceps contractions (quadriceps setting), Straight leg raisings in supine position, Short arc movements (10° to terminal extension), Seated knee extension, Leg adduction exercises in lateral decubitus position along with Therapeutic Ultrasound and McConnell Taping - 5 weeks 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  24.00 Year(s)
Gender  Both 
Details  Symptoms of PSFS for at least 3 months.
Having pain between 3 to 6 in Numeric Pain Rating Scale (NPRS).
Having knee pain at least in two activities among stair ascent and descent, prolonged sitting with the knees flexed, squatting over 90 degrees, running, jumping and kneeling.
Experiencing pain in one of the following clinical tests:
1.Pain during Apprehension test.
2.Pain or tenderness during McConnell Test.
3.Pain during resistance is applied on superior border of patella during isometric contraction of the quadriceps (Clarke’s test).
 
 
ExclusionCriteria 
Details  History of knee surgery, bursitis and arthritis.
History of patella subluxation or dislocation, anterior or posterior cruciate ligament insufficiency.
Referral pain from spinal cord or nerve roots.
Ligament rupture, articular capsule or meniscus injury.
Tendon and muscle ruptures in lower extremity. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
Ultrasound Imaging  5 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
Numeric Pain Rating Scale (NPRS)  5 weeks 
Anterior Knee Pain Scale (AKPS)  5 weeks 
Triple Hop Test  5 weeks 
 
Target Sample Size   Total Sample Size="75"
Sample Size from India="75" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   01/04/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="8"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

This research investigates the effectiveness of Open Kinetic Chain (OKC) and Closed Kinetic Chain (CKC) exercises on quadriceps muscle thickness, pain, and functional performance in recreational players with Patellofemoral Pain Syndrome (PFPS). PFPS is a common condition that leads to knee pain, particularly in athletes and active individuals, affecting their daily activities and performance. The study aims to fill the gap in existing literature by comparing the effects of OKC and CKC exercises, which are widely used in rehabilitation, on improving quadriceps function and alleviating symptoms in recreational athletes. The study will involve 75 participants, randomly assigned to three groups: OKC exercises, CKC exercises, and conventional therapy. The interventions will include exercises along with therapeutic ultrasound and McConnell taping. Outcome measures will include ultrasound imaging for muscle thickness, the Numeric Pain Rating Scale (NPRS) and Anterior Knee Pain Scale (AKPS) for pain and function, and the Triple Hop Test for functional performance. The results will be analyzed using ANOVA to determine the significant differences between the exercise groups. This study will provide valuable insights into the most effective rehabilitation strategies for managing PFPS in recreational players, helping to improve their muscle strength, reduce pain, and enhance functional capabilities.

 
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