Pulp regeneration continues to receive increasing research attention. Regenerative endodontic procedures (REPs) have been associated with revascularization procedures originally proposed more than 50 years ago. Effective sealing at both the apical and coronal ends of a disinfected root canal system are the essential requisites of a successful root canal treatment. Gutta-percha along with a sealer has been the material of choice for obturating the root canals. The periapex contains a variety of progenitor cells which may participate in the regeneration of tissues as a response to injury. Thus, regeneration rather than replacement of tissues with an artificial substitute is the alternative direction in which endodontics is progressing. Biodentine was developed as a new class of dental material, introduced in 2010 by Gilles and Olivier which could conciliate high mechanical properties with excellent biocompatibility, as well as a bioactive behavior. Biodentine is a new tricalcium silicate (Ca3SiO5) based inorganic restorative commercial cement and advertised as ‘bioactive dentine substitute’. The material is claimed to possess better physical and biological properties compared to other tricalcium silicate cements such as mineral trioxide aggregate (MTA) and Bioaggregate(Bioaggregate).  It is used for crown and root dentin repair treatment, repair of perforations or resorptions, apexification, root-end fillings and as permanent dentine substitute in large carious lesions.