Title - AN OPEN LABELLED SINGLE ARM PROSPECTIVE
CLINICAL TRIAL TO EVALUATE THE EFFICACY OF RAKTACHANDANADI LEPA IN VYANGA W.S.R.
TO MELASMA Aim - · To assess the efficacy of Raktachandanadi lepa in
the management of Vyanga. Objectives
- · To elaborate the Ayurvedic etiopathology and
symptomatology of Vyanga and identify its correlation with
melasma. · To
discuss the treatment principles mentioned in various Samhita for the
management of the disease vyanga. Introduction
- Vyanga has been described under kshudra roga by
Acharya Sushruta and Acharya Vagabhatta. Kshudra roga,
as the name suggests, are generally not very significant diseases
in terms of causing suffering to patients yet, these are difficult to get rid
of. Vyanga is caused due to anger and physical
exertion which vitiates vata and pitta doshas
which in turn reflect the classical symptoms of vyanga such
as aruja (painless), tanu (thin
layered), shyava (dark colored /brown), mandal (circular
patches) on face. Clinical features
of melasma are similar to those of vyanga. Melasma is most common
pigmentary disorder with symmetrical brown patches and irregular edges. It is
also known as chloasma or mask of pregnancy. Causes of melasma are unknown
but probable factors include UV radiation, cosmetic procedures, oral contraceptive
pills and hormonal disturbances. Need of
research - MELASMA is common
pigmentary disorder in India with prevalence of 0.25-4%. There
are many treatment principles in classical text to treat vyanga but lepana plays
a vital role as it is applied directly on the affected part. Vyanga is
such a condition which affects the beauty as well as personality so, person may
suffer from inferiority complex, anxiety, isolation etc. This study therefore
aims to testify the result of raktachandanadi lepa in the
management of vyanga on the contrary of chemical peeling,
laser, microneedling. Also, this study aims to improve care coordination and
communication in order to advance the diagnosis of melasma and improve
outcomes. Study Design
- Study Type:
Interventional Purpose: Treatment Masking: Open
Labelled, Clinical Trial Direction:
Prospective End point:
Efficacy No. of Groups:
single Group Sample Size: 50
Patients Probable Mode
of Action of Drug - Raktachandanadi
Lepa incorporates various ingredients traditionally believed to ameliorate skin
health and appearance.The blend of dravya (herbal constituents) in this
formulation works synergistically to enhance skin luster and reduce dryness.
This lepa is applied locally on the face, promoting improved skin texture and
minimizing discoloration through its various beneficial properties, including
twakdoshahara which helps in skin ailments Raktachandana which is known for its blood-purifying
properties. Manjishtha which
supports even skin tone. Lodhra which is Raktapittanut,
Kaphapittanut Kushtha having Raktashodhak, Kushthaghna,
Varnya properties Priyangu is also Raktashodhak,Twagdoshahar Vatankur which is Varnya, kaphapittahar Masur having Varnykar properties to
improve skin texture. Treatment regimen - Drug: Raktachandanadi lepa Form: Lepa Treatment Duration: 21 Days Follow up: 6 months Thickness of lepa: According to Maharshi
Sharangadhara the thickness of the Varnya Lepa should
be ½ (9.75mm) Angula Dose:
Quantity required as per the area of the affected part.
|