Laparoscopic cholecystectomy is a minimally invasive surgical procedure used to remove the gallbladder, typically due to gallstones or other gallbladder diseases. However, one potential complication of the procedure is bile duct injury (BDI), which occurs when the bile duct is accidentally cut, clipped, or otherwise damaged during the procedure. Reported incidence of BDI varies between 0.2% to 0.7% but it can lead to serious complications such as bile leakage, infection, biliary peritonitis and even long-term health problems if not promptly identified and treated in addition to increased hospital stay and need for further interventions. Intraoperative cholangiography has been a traditional method used to visualize the bile duct anatomy during cholecystectomy but it involves injecting contrast dye into the bile duct and taking X-ray images to identify any abnormalities or injuries. It requires special expertise in technique and its interpretation, additional equipment, radiation exposure, and prolongs the surgical procedure. 

An emerging alternative to Intraoperative cholangiography is the use of indocyanine green (ICG) fluorescence imaging. ICG is a fluorescent dye that can be injected intravenously and visualized using specialized imaging systems during surgery. By selectively highlighting the bile duct and surrounding structures, ICG fluorescence imaging allows surgeons to better identify and avoid injuring the bile duct during LC. 

However, the timing of ICG administration plays a crucial role in adequate fluorescence of the extra hepatic bile ducts. The reason for this being background fluorescence from liver distorting the perception of bile ducts. If fluorescence imaging is performed immediately after the administration of ICG, the liver will be highly fluorescent while bile ducts will not yet contain enough ICG. On the other hand, if fluorescence imaging is performed too long after the administration of ICG, the fluorescence intensity of the common bile duct (CBD) and liver will be so low that it wouldn’t be conducive to identifying anatomical structures.

Hence in this context, the study being conducted to assess the optimal timing of ICG administration before Laparoscopic Cholecystectomy to enhance the visualization of extra hepatic bile ducts during surgery.