Vamana karma is considered as the pradhana karma indicated for purification of upper part of body by inducing therapeutic vomiting. Amashaya and ura pradesh are the sthanas for kapha¹. As per general principle of ayurveda, vitiated doshas should be expelled out through nearest route i.e. by oral route for kapha dosha.

 Many Vamaka Dravyas are mentioned in bhritrayees, among them madanphala (Randia dometorum) is considered as the best vamaka dravya (emetic drug) because of its ‘anapayikatwa guna’ means having very less complications and  is safer to use.

 Neurotransmitter are the mediators or chemical messengers which impact the induction of Vamana. This study is to create an evidence regarding changes in neurotransmitter level with respect to vamaka dravyas . In ayurveda principles, vamana is explained in terms of utklesh lakshana such as sweda pradhurbhava, lomharsh, kukshi adhyamana, hrullassa And samyak shudhhi lakshanas such as langiki, vaigiki, antiki and mainki. It is believed that neurotransmitters may play a major role in induction of vamana karma so to create an evidence this study has been initiated to visualize and create the data of impact of neurotransmitter on vamana karma with respect to usage of madanphala yoga which may guide in future.