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CTRI Number  CTRI/2025/04/085248 [Registered on: 21/04/2025] Trial Registered Prospectively
Last Modified On: 19/04/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Other (Specify) [Raga Therapy]  
Study Design  Other 
Public Title of Study   Benefits Of Indian Classical Ragas On , Blood Pressure, And Reaction Time in Adults. 
Scientific Title of Study   Impact Of Indian Classical Ragas On Heart Rate, Blood Pressure, And Audio-Visual Reaction Time on Young Adults. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Aryan Malaviya 
Designation  MBBS Student 
Affiliation  Manipal Tata Medical College 
Address  Department of Physiology Manipal Tata Medical College Kadani Road, Baridih, Jamshedpur

Purbi Singhbhum
JHARKHAND
831017
India 
Phone  8318645907  
Fax    
Email  aryanmalaviya26@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  VINAY A V 
Designation  Professor  
Affiliation  Manipal Tata Medical College 
Address  Department of Physiology Manipal Tata Medical College, Kadani road, Baridih, Jamshedpur

Purbi Singhbhum
JHARKHAND
831017
India 
Phone  9880966679  
Fax    
Email  vinay.av@manipal.edu  
 
Details of Contact Person
Public Query  
Name  VINAY A V 
Designation  Professor  
Affiliation  Manipal Tata Medical College 
Address  Department of Physiology Manipal Tata Medical College, Kadani road, Baridih, Jamshedpur

Purbi Singhbhum
JHARKHAND
831017
India 
Phone  9880966679  
Fax    
Email  vinay.av@manipal.edu  
 
Source of Monetary or Material Support  
Department of Physiology Manipal Tata Medical College, Jamshedpur, East Singhbhum District, Jharkhand, India-831017 
 
Primary Sponsor  
Name  Aryan Malaviya 
Address  Department of Physiology Manipal Tata Medical College, Kadani road, Baridih, Jamshedpur East singhbhum district, Jharkhand, India-831017 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Vinay A V  Manipal Tata Medical College  Department of physiology Manipal Tata medical College, Kadani Road, Baridih, Jamshedpur
Purbi Singhbhum
JHARKHAND 		 9880966679

vinay.av@manipal.edu 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Manipal Tata Medical College Institutional Ethics Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Must listen to various Ragas 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Classical Ragas  Listening to classical Ragas for 10 minutes 
Comparator Agent  NIL  NIL 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  25.00 Year(s)
Gender  Both 
Details  1.MBBS Students
2.Age group between 18 to 25 years.
3.Volunteers willing to participate in the study 
 
ExclusionCriteria 
Details  1.Individuals suffering from fever, cough, vomiting, or other illness affecting their daily routine.
2.Individuals with a history of daily alcohol intake, tobacco chewing, and smoking.
3.Individuals on any medications like anti-depressants, antipsychotics, and psychotropic drugs.
4.Individuals suffering with any neurological, psychiatric, CVD, or metabolic diseases
5.Individuals with sleep disturbances and disorders. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Impact of Raga Bhiravi and raga Bhupali on Heart rate and blood pressure and audiovisual reaction time  Blood Pressure and Audiovisual reaction time will be assessed before and immediately after listening to the classical ragas for 10 minutes 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   04/05/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Nature has bestowed upon mankind with innumerable sounds, vibrations and energies. Our Indian Classical Music is one of the byproducts of this gift of nature. Raga is a combination of notes in an ascending or descending order.1 Every raga has a unique essence, feeling(rasa), and emotional content(bhava).2 Listening to the right raga at the right time is said to smoothen the natural transitions and attune the body and mind to the circadian cycle.3 Music has been reported to decrease blood pressure, heart rate (HR), respiration rate, anxiety and pain with improved quality of sleep, pre competition stress in athletes etc. in many research studies.4 The vagus nerve, cranial nerve X, is located near the eardrum and responds to musical vibrations by triggering the body to relax. This pathway may explain the study observations which found lower systolic blood pressure after listening to slow, classical music.5

Reaction time measurement is an indirect index of processing capability of central nervous system and simple means of determining sensory motor association and performance of an individual.6 Cognitive disorders, like Alzheimer’s disease, Attention deficit disorder, Dementia, Epilepsy-related cognitive dysfunction all deals with slow Reaction time. So Indian classical music can be used in disorder that is characterized by perception, information processing, or motor problems. Indian ragas could be a safe alternative for many medical interventions.7                                    

Diverse ragas exhibit varying impacts on our physiological systems, yet this research specifically examines the influence of Raga Bhairavi and Bhupali. In the literature, Raga Bhairavi has been known to induce calmness and spiritual well-being significantly.2 The Raga Bhupali, equivalent to the Lydian mode of Western music instills the shringara rasa or aesthetic mood of love within the listener.3 It is a great raga to bring us back to a calm state.7

Although music is predominantly utilized for religious, enjoyment or entertainment purposes, it is gradually emerging as a promising non-pharmacological intervention for improving health outcomes in both healthy and diseased populations, especially in those with cardiovascular diseases.8              

This study was envisioned to assess the impact of classical ragas on cardiovascular and cognitive function, for the probable utilization of these ragas as adjuvant therapy in regulating cardiovascular and cognitive parameters.

 
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