1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [endobyvineeta@gmail.com].
   


6. For how long will this data be available start date provided 02-03-2027 and end date provided 01-03-2032?
   Response - Beginning 9 months and ending 36 months following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - Nil

Large periapical lesion (LPL) of endodontic origin are primarily caused by bacteria and their by-products emanating from the root canal system. These lesions are expected to heal if the source of infection (intracanal bacteria and bacterial-by products) is eradicated. Non-surgical root canal treatment (NSRCT) has a good success rate for management of LCPL. However, NSRCT may require multiple visits. Hence, in many cases surgical intervention may be required. Despite the advances in periapical surgeries, some cases of LPL cannot be managed surgically due to surrounding anatomical or neurovascular structures (e.g.; proximity to the mental nerve or maxillary sinus), or lack of accessibility (e.g.; thick buccal bone, endodontic-periodontal lesion, repair of a palatal radicular groove or extensive root perforation). Moreover, periapical surgery is an invasive procedure which takes long intraoperative time period with possibility of post-operative swelling and pain. Intentional replantation (IR) is defined as a deliberate extraction of tooth, following which the tooth undergoes inspection, endodontic manipulation and repair and is then replanted back into the same socket . Intentional replantation (IR) results in elimination of diseased tissue, removes apical

ramifications and provides a better quality of apical seal due to the improved access and ease of manipulation. IR addresses both intraradicular and extra-radicular infection. In this regard, it offers benefits of both non-surgical endodontic treatment and peri-apical surgery. It offers several advantages with reduced morbidity; less invasive; less technique-sensitive procedure that can potentially be done by general dental practitioners and is more cost-effective. Moreover, IR is done within 15-20 minutes, with very less postoperative complications. The aim of the study is to evaluate and compare the CBCT outcome of non-surgical root canal treatment with intentional replantation and periapical surgery performed for management of maxillary anterior large periapical lesion of endodontic origin.