Now a days PCOS is rapidly raising globally due to sedentary lifestyles, lack of exercise, more intake of junk food, stressful life etc. However, Infertility, Diabetes mellitus, Endometrial cancer, Metabolic Syndrome, Endometrial Hyperplasia, Hypertension and Cardiovascular disease are the most worrisome medical outcomes. Current modern medical and surgical treatments for PCOS have many limitations like use of metformin for insulin resistance, ovulation induction agents like clomiphene citrate, human menopausal gonadotropins (HMG), laparoscopic ovarian drilling for ovulation induction, OCP (Oral Contraceptive Pills) etc. No single definitive and successful modalities are known to the day. In order to overcome these limitations and invasive therapies with side effects an effective treatment empowered by the principles and practice of Ayurveda is essential.Due to the multifactorial etiology and involvement of Dosha Dushya Sammurchhana at the cellular level, Shodhana is essential part of Ayurvedic management of PCOS along with Shamana. Numerous databases were explored through, but effect of vamana karma along with kuberaksha vati on PCOS profile in patients of PCOS have not been well studied yet.  So, to establish a standard of care in PCOS, the current study  has been planned with all previous hypothesis in mind as well as the findings of previous research studies. By this, we will have a deeper understanding of the changes that ’vamana karma’ along with kuberaksha vati brings about on the various hormones in PCOS patients, we will eventually be able to collect evidence based data on how vamana along with kuberaksha vati is effective in the management of PCOS from the novel perspective of the PCOS profile.