Breast cancer is the most prevalent cancer among women worldwide and represents nearly a quarter of all malignant tumors in women, with over one million new cases diagnosed annually. It is a complex and heterogeneous disease characterized by diverse histological patterns, biological features, and clinical behaviors. While advancements in early detection and treatment have improved survival rates, persistent treatment-related symptoms, such as dyspnea, fatigue, and lymphedema, significantly impact the quality of life for survivors. These symptoms are often underdiagnosed and inadequately managed, particularly respiratory impairments linked to chemotherapy and radiotherapy, including pulmonary toxicity from agents like docetaxel. Inspiratory Muscle Training (IMT) and Positive Expiratory Pressure (PEP) IMT have shown promise in improving respiratory function and endurance, but their role in managing dyspnea and enhancing quality of life in breast cancer patients undergoing treatment remains underexplored. Addressing this gap, this study aims to evaluate the effectiveness of IMT and PEP IMT within a cardio-oncology rehabilitation framework. By examining their impact on dyspnea, fatigue, lymphedema, and overall quality of life, the research seeks to provide evidence-based insights to optimize care for breast cancer patients undergoing chemo-radiotherapy, advancing toward more holistic and effective treatment strategies.

Null Hypothesis H₀ - There is no significant effect of PEP IMT than traditional methods in cardio-oncology rehabilitation on dyspnea, fatigue, lymphedema and quality of life in breast cancer patients receiving chemo-radiotherapy.

Alternate Hypothesis H¹ - There is significant effect of PEP IMT than traditional methods in cardio-oncology rehabilitation on dyspnea, fatigue, lymphedema and quality of life in breast cancer patients receiving chemo-radiotherapy.