The study will be conducted in 90 patients between 18 to 60 years of age , ASA physical status1 and 2 of either gender with elective upper limb surgeries of forearm and hand surgeries.

 Patients were randomly allocated in to one of the following groups of 45 each.

 Group RC-Retroclavicular approach Group 

 Group SC-Supraclavicular approach Group

 All the patients in the study will be subjected to a thorough pre-anesthetic evaluation which includes a detailed history taking, complete general physical examination and necessaryr elevant investigations like complete blood count,blood urea, serum creatinine, chest X ray, ECG, Bleeding time, Clotting time, random blood sugar, and urine analysis (Sugar,Albumin and microscopy).

 All the patients will be kept Nil per oral according to standard guidelines. Tablet Alprazolam 0.5mg and Tablet Pantoprazole 40mg will be given on the day before surgery, at 6AM on the day of surgery Injection Pantoprazole 40mg will be given. For administration of fluids and drugs, Intravenous line will be secured. Pre-operatively, The Numerical Rating Scale will be explained to the patient, and intensity of pain will be evaluated on a scale of 0-10. 

A score of 0 indicates No Pain, while a score of 10 indicates worst possible pain. The patient will be shifted to preoperative room and multiparameter monitor will be connected and preoperative Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure, Respiratory Rate, Oxygen Saturation, ECG will be recorded and Intravenous fluids will be connected.

 USG GUIDED RETROCLAVICULAR AND SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK 

 All the patients will receive 20ml of 0.5% Ropivacaine. The patient is made to lie in supine position with head end angled at 45 degrees to the ipsilateral arm placed adducted by the patient’s side. Procedure is performed by Experienced anesthesiologist. The skin over the needle insertion site i.e., Supraclavicular area will be prepared with 5% povidine iodine solution. Block will be performed by using 6 to 12mHz frequency Linear probe of GE logic C5 premium USG machine. 

 In Supraclavicular approach, the probe will be placed over the Supraclavicuar fossa, parallel to the clavicle to obtain a view of the divisions of the brachial plexus which appears as a cluster of hypoechoic structure and subclavian artery which is seen as a pulsating structure over 1st rib. After the skin is infiltrated with local anesthetic mixture, a 50mm 20G insulated short Beverley stimulation needle (stimuplex A, B Braun) will be inserted using in plane technique in a lateral to medial direction until the needle tip is positioned at the junction of 1st rib and subclavian artery.

 Once the needle tip penetrates Brachial plexus sheath on ultrasound, after negative aspiration for blood and air, local anesthetic will be deposited using single injection technique. 

In Retroclavicular Approach, the probe will be placed below and perpendicular to the clavicle, in paramedian Sagittal plane, medial to coracoid process, to obtain the view of the cords of brachial plexus and axillary vessels. The needle will be inserted in the Supraclavicular fossa, posteriorly to the clavicle and advanced in plane and parallel to the ultrasound transducer.

 Again, once the needle penetrates the brachial plexus sheath on ultrasound, after negative aspiration for blood and air, the local anesthetic mixture will be deposited using single injection technique. 

 Motor blockade will be assessed by using modified Bromage scaling 

Grade 0 Normal motor function with full flexion and extension of joint of upper limb, namely the elbow, wrist and fingers. 

Grade 1- will be identified when there is a decrease in motor strength with the patients able to move the fingers only. 

Grade 2- will be considered when there will be complete motor block and the patients will be unable to move their fingers. 

 Sensory blockade will be evaluated using pinprick method using 23G Hypodermic 1,3,5,7,10 and every 5 min in radial, ulnar, median and musculocutaneous nerve territory. 

 Grading of sensory blockade will be taken as

 Grade 0- Sharp pinprick sensed 

Grade 1 Touch sensation on pinprick 

Grade 2- Not even touch sensation.

 Onset of sensory blockade will be time interval between complete administration of local anaesthetics to the loss of sensation in all 4 nerve territories, duration of sensory block is from complete sensory till NRS score reaches 4 or more. Duration of sensory block is the time from the injection of local anesthetic to the time the patient recovered full sensation of the upper limb. Onset of motor block is defined as from completion of drug injected till it reaches modified Bromage scale 2. Duration of motor block is the time from injection of local anesthetic to the time the patient recovers with full function of the arm. Needling time is the time interval between needle insertion through the skin wheal and the end of local anesthetic injection. Imaging time is the time interval between probe placement and needle insertion. Performance time is the sum of the imaging and needling time. Intraoperatively patient will be assessed pulse rate, SBP, DBP, SpO2 and RR were monitored every 5 minutes for first 30 minutes and then every 15 minutes till end of surgery. Any side effects such as Nausea, vomiting, hematoma, desaturation and respiratory distress will be seen and treated accordingly. Postoperatively patient will be assessed every 2nd hourly till NRS score reaches 4 or more at that time. Rescue analgesia Inj. Diclofenac 75mg will be given and time will be noted which will be considered as Rescue analgesia time.