This prospective observational cohort study aims to assess the predictive value of serum D-dimer and procalcitonin levels at admission in determining the severity of acute pancreatitis (AP). The study will include adult patients (18–70 years) presenting within 24 hours of symptom onset. The Revised Atlanta Classification and Modified Marshall Scoring System will be used to classify AP severity and assess organ dysfunction. Given the associations of AP with systemic inflammation, sepsis, and microvascular thrombosis, procalcitonin and D-dimer levels may serve as early biomarkers for severity assessment. A total of 62 patients will be recruited, accounting for a 10% dropout rate. Blood samples will be collected at admission for D-dimer and procalcitonin measurements. Patients will be monitored for up to 8 days or until discharge for development of complications, organ failure, and outcomes. Data will be analysed using SPSS, with ROC curve analysis to evaluate the predictive accuracy of both biomarkers. Multiple regression will identify independent predictors of severity and mortality. The study seeks to establish whether these biomarkers can aid in early risk stratification and guide clinical decision-making in acute pancreatitis.