AIM- To comparatively evaluate the efficacy of different premedication agent in anxious children under oral melatonin, intranasal midazolam and nitrous oxide sedation in age group of 4 to 7 years during local anaesthetic administration.

Material & Methodology- In a randomized study, 60 children with age group 4 to 7 with Frankl’s behavior rating scale 2 and 3, received premedication, Group A- 3 mg/kg per dose of Oral melatonin 60 minute before the procedure (n=20), Group B- 0.2 mg/kg intranasal midazolam 60 minute before the local anaesthetic administration (n=20), Group C- preadjusted mixture of nitrous oxide–oxygen sedation was administered in the concentration of 30–70% using Matrx Porter Digital Relative analgesia machine (n-20).

Subjective pain perception during injection was measured using Wong Baker Faces Pain Rating Scale and objective pain by sound, eye, body movement rating scale and Modified Dental Anxiety Scale score before and after local anaesthesia administration, patient satisfaction and comfort levels scores.