Acne vulgaris is a common cutaneous inflammatory disorder of the pilosebaceous unit, which runs a chronic course. The condition typically manifests with papules, pustules, or nodules primarily on the face, although it can also affect the upper arms, trunk, and back. Along with its polymorphic clinical presentations, it has the potential to cause varying degree of scarring. Recent research has provided insights into the role of the sebaceous gland and the pro-inflammatory activity of the cutaneous microbiome. During puberty, alteration of the sebaceous lipid profile, called dysseborrhoea, stress, irritation, use of cosmetics and potential dietary factors lead to inflammation and formation of different types of acne lesions. Additionally, dysbiosis, the process leading to a disturbed skin barrier and disequilibrium of the cutaneous microbiome, resulting in the proliferation of P. acnes strains, is another important process that triggers acne. Following screening using specific selection (inclusion and exclusion criteria) criteria and obtaining consent, eligible 90 participants will be included in the trial (45 in each group). Individualized Homoeopathic medicines will be prescribed either in Centesimal potency or 50-millesimal (as per random number chart) after proper Case-taking, consultation with Materia medica and Repertory. Following that, the outcomes will be assessed initially at the baseline, and every one month up to 3 months, as per GAGS score, CADI scale and DLQI scale.