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CTRI Number  CTRI/2025/03/082432 [Registered on: 17/03/2025] Trial Registered Prospectively
Last Modified On: 22/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Yoga & Naturopathy 
Study Design  Randomized, Crossover Trial 
Public Title of Study   "Influence of ujjayi pranayama on blood pressure balance in healthy individuals." 
Scientific Title of Study   Immediate effect of ujjayi pranayama on cardioautonomic variables among young healthy volunteers a randomized cross over study  
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Govindan P 
Designation  PG Scholar 
Affiliation  SDM College of Naturopathy and Yogic sciences, Ujire, 
Address  Department of yoga Therapeutics, SDM College of Naturopathy and Yogic sciences, Ujire, near siddavana, Belthangady

Dakshina Kannada
KARNATAKA
574240
India 
Phone  9902980062  
Fax    
Email  Govindpadmanabh1234@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Govindan P 
Designation  PG Scholar 
Affiliation  SDM College of Naturopathy and Yogic sciences, Ujire, 
Address  Department of yoga Therapeutics, SDM College of Naturopathy and Yogic sciences, Ujire, near siddavana, Belthangady


KARNATAKA
574240
India 
Phone  9902980062  
Fax    
Email  Govindpadmanabh1234@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Bindu G V 
Designation  Assistant Professor 
Affiliation  SDM College of Naturopathy and Yogic sciences, Ujire, 
Address  Department of Clinical Naturopathy, SDM College of Naturopathy and Yogic sciences, Ujire, near siddavana, Belthangady

Dakshina Kannada
KARNATAKA
574240
India 
Phone  8277614169  
Fax    
Email  bindu.shridhar@gmail.com  
 
Source of Monetary or Material Support  
SDM College of Naturopathy and Yogic sciences, Ujire, near siddavana, Belthangady, Dakshina Kannada, Karnataka, 574240 
 
Primary Sponsor  
Name  Dr Govindan P 
Address  Department of Yoga Therapeutics, SDM College of Naturopathy and Yogic sciences, Ujire, near siddavana, Belthangady, Dakshina Kannada, Karnataka, 574240 
Type of Sponsor  Other [SELF] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Govindan P  Department of yoga therapeutics ,SDM Yoga and Nature cure hospital  Shanthivana, near Dharmasthala, Ujire, belthangady
Dakshina Kannada
KARNATAKA 		 09902980062

Govindpadmanabh1234@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
SDM College of Naturopathy and Yogic Sciences, Ujire  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Healthy Human Volunteers 
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Relax in a sitting position   Relax in a sitting position with open eyes, restricting movements and gestures for 10 min. Duration : 10 minutes 
Intervention  Ujjayi Pranayama  1. Sit in any comfortable meditative asana. 2. Close the eyes and relax the whole body. 3. Take the awareness to the breath in the nostrils and allow the breathing to become calm and rhythmic. 4. Feel the air passing down the windpipe, inhale and slightly contract the epiglottis ,region at the back of the throat 5. After inhalation retain the breath, closing the nostrils with right hand and lower the head to perform Jalandhara bandha. 6. Slowly release the jalandhara bandha, raise the head with hissing sound, and exhale slowly through the left nostril only. 7. Practice yogic breathing while concentrating on the sound produced by the breath in the throat. The sound of the breath should not be very loud. It should just be audible to the practitioner but not to another person unless they are sitting very close. Duration of the practice: 8 minutes ujjayi pranayama, at rate of 6 breaths per minute followed by natural breath awareness.  
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  26.00 Year(s)
Gender  Both 
Details  Willingness to participate in the research 
 
ExclusionCriteria 
Details  1. Individuals with pre-diagnosed comorbidities.
2. Any Systemic diseases.
3. Individuals with recent surgeries, traumatic injuries, and infections.
4. Individuals with hypotension or any cardiac issues.(25)
5. Subjects with a history of alcohol and smoking.
6. Pregnancy and lactation.
7. Female subjects during menstruation.
 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   An Open list of random numbers 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
Heart Rate Variability
Galvanic Skin Response
Blood Pressure
 		 Baseline, During the intervention and 5 minutes after the intervention 
 
Secondary Outcome  
Outcome  TimePoints 
Rate pressure product
 		 Baseline, During the intervention and 5 minutes after the intervention 
 
Target Sample Size   Total Sample Size="94"
Sample Size from India="94" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   24/03/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Open to Recruitment 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary
Modification(s)  		 To be healthy, maintaining equilibrium between the internal and external environments is essential and the process is  known as homeostasis. The body’s physiologically active systems, including the neurological, digestive, and cardiovascular systems, are all involved in maintaining homeostasis. The Autonomic Nervous System (ANS) is crucial in regulating the body’s internal environment in response to changes in the environment outside.
There is growing evidence that physiological and psychological stress disrupts autonomic balance and prolonged autonomic imbalance is associated with a wide range of somatic and mental diseases. Such autonomic imbalance is reflected in measures of heart rate variability (HRV), which have been positively associated with aerobic fitness, resilience to stress, and psychological and physiological flexibility and negatively associated with cardiovascular disease, stress, neuronal atrophy, negative affective states, and maladaptive stress responses.
Yoga has an impact on cardiovascular autonomic regulation. They regulate the heart rate, systolic and diastolic blood pressure and the ANS. Slow pranayama and yoga relaxation raise parasympathetic activity while lowering sympathetic activity. By balancing the sympathovagal stress response properly, these techniques improve cardiovascular health.
 In the traditional text, Hatha yoga Pradeepika Ujjayi pranayama is recommended for insomnia and mental tension. The simple form, without retention, is in the yogic management of heart disease. Ujjayi resistance breathing, a breathing practice taught by the yogic tradition, reduces airflow, and during expiration it increases the intrathoracic pressure due to a slight contraction of the glottis muscles, potentially resulting in intensified vagal activity.

To assess the immediate effect of Ujjayi pranayama on Cardio Autonomic variables among healthy young volunteers. 


 
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