Ayurveda, an ancient science of life, focuses on maintaining balance for health and longevity. It divides health principles into eight branches, one of which is Agad Tantra, dealing with poisons and their treatment. Acharya Charak emphasized that poisons, when properly prepared, can become medicines, and conversely, even beneficial medicines can become toxic if used incorrectly. A key part of Ayurveda is understanding Tridosha—the balance of Vata, Pitta, and Kapha. When these energies are in equilibrium, health prevails; imbalances lead to diseases.

One such disease is Gridhrasi, similar to sciatica in modern medicine, characterized by pain, stiffness, and restricted leg movement. It arises from imbalances in Vata, and in some cases, also Kapha. Sciatica is a common condition, caused by issues like poor posture, prolonged sitting, and obesity. It affects many individuals, especially those aged 30-50, and often leads to pain, disability, and discomfort.

In Ayurveda, treatments such as Vishtinduka Taila (derived from Strychnos nux-vomica, a poisonous plant) and Vatari Guggulu (a herbal remedy) are used for conditions like Gridhrasi. These treatments have properties like pain relief, anti-inflammatory, and nerve tonic effects. However, the toxic potential of these treatments, especially from the use of Vishtinduka, requires careful evaluation. Toxicity studies in animals are essential to ensure their safety for human use.

This study aims to evaluate the safety of Vishtinduka Taila through dermal exposure in rats and its clinical effectiveness in treating Gridhrasi. Additionally, Vatari Guggulu’s non-toxic profile has already been established. The ultimate goal is to find an effective, safe treatment for sciatica, using traditional Ayurvedic remedies.