Diabetes mellitus (DM) is defined as a disturbance of intermediary metabolism, manifesting as a chronic sustained hyperglycemia primarily due to either an absolute or relative lack of insulin. It is a metabolic disorder characterized by polyuria, polydipsia, weight loss, fatigue etc., sometimes associated with complications of retina, kidney, and nervous system. India has already become the “ Diabetes Capital” of the world, with over 3 crore affected patients, which is a tip of iceberg. Despite the availability of conventional treatments like Metformin, achieving optimal glycemic control in T2DM remains a challenge for many patients. Additionally, concerns regarding side effects and long-term sustainability of pharmacological interventions signifies the need for exploring alternative therapies. Though there are so many ongoing and completed studies on efficacy of Ayurvedic management of DM, most of them shows is effective in reducing the subjective parameters and no much change is observed in FBS, PPBS and is recommended to carry out the study in a larger number of patients. Investigating the efficacy of Chandrakala gutika in comparison to Mamajjaka Ghanavati offers an opportunity to diversify treatment options and potentially improve outcomes. Therefore, keeping all these facts in mind, it has been decided to conduct a clinical study entitled as “RANDOMISED COMPARATIVE CLINICAL TRIAL TO EVALUATE THE EFFICACY OF CHANDRAKALA GUTIKA AND MAMAJJAKA GHANAVATI IN THE MANAGEMENT OF MADHUMEHA WITH SPECIAL REFERENCE TO DIABETES MELLITUS TYPE II”