Kshinashukra is a burning problem of today’s era which not only affects the somatic part of body but also affect psychological health. Kshinashukra is variety of Shukradushti eventually leading to infertility and the same in biomedicine is referred as oligospermia. As per Ayurveda, oligospermia can be co-related with Kshinashukra. The prevalence of infertility in general population affects around one in eight couples of reproductive age, with a male factor being solely responsible in 20% and contributory in an additional 30% of cases.

The drugs that are selected in this research are Kaunchadi Granules which are selected as trial drug. And tablet clomiphene citrate standard drug In Kshinashukra mainly involvement of Vata Dosha. Kaunchadi Choorna possesses Vrishya property.Guptaphala (Kauncha)and Gokshura have Madhura Rasa, Guru, Snigdha Guna, Seeta Veerya, Vrishya, Rasayana, Brimhana and Vattapittahara properties. Uchchata (Bhumyamalaki) has Madhura, Tikta, Kashaya Rasa, Laghu, Ruksha Guna, Sheeta Veerya and Balya. Milk has Madhura Rasa, Guru, Snigdha Guna, Sheeta Veerya, Madhura Vipaka, Rasayana, Brimhana, Vattapittahara and Sharkara is having properties of Madhura, Sheeta Veerya, Satmya, Shukravardhaka, Balya, Jeevaniya.  All drugs have Vatapittahara property which helps in Samprapti Vighatana of Ksheena Shukra as it is Vatapitta predominant disease. However, Madhura Rasa, Snigdha, and Guru Guna increase the Shukra Dhatu qualitatively and quantitatively^. It can increase the Testosterone by increasing the luteininzing hormone and the gonadotropin releasing hormone. Combination of drugs having adaptogenic, antioxidant, and aphrodisiac properties effectively have multifaceted sexual health benefits.

The following investigations will be carried out before & after treatment to rule out other pathogenesis and assessment the status of subjects. Semen Analysis- (Physical examination, Microscopic examination, Other abnormalities), Hematological Examination - Hb%, TLC, DLC, ESR, Urine –Albumin, Sugar & microscopic, Bio-chemical investigation- RBS, Sr.Testosterone test and Serology Examination (HIV, HBsAg, HCV, VDRL),special laboratory test (FSH, LH, TSH) USG of Abdomen and Pelvis, Scrotum (Only BT). The participation in this research is entirely voluntary. In this present research work, 30 clinically diagnosed patient of Ksheenashukra (Oligospermia) will be registered and randomly divided into two groups. In Group A, Patients will be given Kaunchadi Granules (trial drug) every morning before breakfast, orally, 12 grams with milk twice a day for 90 days.

 In Group B, Clomiphene citrate tablet orally, 1 tablet (25 mg) with water once a day after food for 90 days. The patient will be withdrawn from study if patient complains of any adverse reaction or having any serious complications occur due to treatment will be referred to the higher centre. The patient will be withdrawn if patient desires to be discontinued treatment protocol. If any adverse drug reaction will be observed then it will be reported to the ADR cell (Pharmacovigilance cell of ITRA, Jamnagar).