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CTRI Number  CTRI/2025/06/088104 [Registered on: 02/06/2025] Trial Registered Prospectively
Last Modified On: 28/05/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Diagnostic 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   using ultrasound for cannulating radial artery for invasive blood preessure monitoring in patients undergoing major surgeries compared to traditional palpatory method 
Scientific Title of Study   Effectiveness of Ultrasound as a tool for Radial artery cannulation compared to the traditional palpatory technique- A Prospective randomized controlled clinical trial 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  KADAVERU LAHARI 
Designation  RESIDENT 
Affiliation  NIZAMS INSTITUTE OF MEDICAL SCIENCES 
Address  DEPARTMENT OF ANESTHESIOLOGY, OLD BLOCK 1ST FLOOR, NIMS, PANJAGUTTA, HYDERABAD, TELANGANA

Hyderabad
TELANGANA
500082
India 
Phone  9502876214  
Fax    
Email  klahari01@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  MONU YADAV 
Designation  PROFESSOR 
Affiliation  NIZAMS INSTITUTE OF MEDICAL SCIENCES 
Address  DEPARTMENT OF ANESTHESIOLOGY, OLD BLOCK 1ST FLOOR, NIMS, PANJAGUTTA

Hyderabad
TELANGANA
500082
India 
Phone  9490213460  
Fax    
Email  monubalbir@yahoo.co.in  
 
Details of Contact Person
Public Query  
Name  KADAVERU LAHARI 
Designation  RESIDENT 
Affiliation  NIZAMS INSTITUTE OF MEDICAL SCIENCES 
Address  DEPARTMENT OF ANESTHESIOLOGY, OLD BLOCK 1ST FLOOR, NIMS, PANJAGUTTA

Hyderabad
TELANGANA
500082
India 
Phone  9502876214  
Fax    
Email  klahari01@gmail.com  
 
Source of Monetary or Material Support  
NIZAMS INSTITUTE OF MEDICAL SCIENCES, PANJAGUTTTA, HYDERABAD - 500082, TELANGANA 
 
Primary Sponsor  
Name  NIZAMS INSTITUE OF MEDICAL SCIENCES 
Address  PANJAGUTTA, HYDERABAD, TELANGANA,500082 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
KADAVERU LAHARI  NIZAMS INSTITUTE OF MEDICAL SCIENCES   DEPT OF ANESTHESIA, OLD BLOCK, 1ST FLOOR, PANJAGUTTA , HYDERABAD, TELANGANA, 500082
Hyderabad
TELANGANA 		 09502876214

klahari01@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
NIMS INSTITUTIONAL ETHICS COMMITTEE  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: 4||Measurement and Monitoring,  
 
Intervention / Comparator Agent  
Type  Name  Details 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  ASA GRADE I TO IV PATIENTS UNDERGOING MAJOR ELECTIVE SURGERIES 
 
ExclusionCriteria 
Details  PAEDISTRIC AND PREGNANT POPULATION
PATIENT DENIAL
NEGATIVE ALLENS TEST
INFECTION AT THE SITE OF CANNULATION
EMERGENCY SURGERIES
VASCULAR MALFORMATIONS
PERIPHERAL VASCULAR DISEASE
COAGULOPATHY
PREVIOUSLY ATTEMPTED ARTERIAL CANNULATION IN THE LAST ONE WEEK 
 
Method of Generating Random Sequence   Random Number Table 
Method of Concealment   An Open list of random numbers 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
TO COMPARE THE SUCCESS RATE OF RADIAL ARTERY CANNULATION WITH TRADITIONAL PALPATORY TECHNIQUE AND USG GUIDED TECHNIQUE IN TERMS OF THE NUMBER OF ATTEMPTS/PUNCTURE SITES.TIME TAKEN FOR SUCCEEFUL CANNULATION  5 SECONDS, 10 SECONDS, 30 SECONDS, 1 MINUTE, 5 MINUTES 
 
Secondary Outcome  
Outcome  TimePoints 
TO COMPARE THE ASSOCIATED IMMEDIATE COMPLICATIONS LIKE HAEMATOMA FORMATION AND VASOSPASM WITH BOTH THE TECHNIQUES  5 seconds, 10 seconds, 30 seconds, 1 minute, 5 minutes 
 
Target Sample Size   Total Sample Size="98"
Sample Size from India="98" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   10/06/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  10/06/2025 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   BLOOD PRESSURE MONITORING HAS BEEN A FUNDAMENTAL CARDIOVASCULAR VITAL SIGN INCLUDED IN THE  STANDARD ASA MONITORING DURING THE PERIOPERATIVE PERIOD AND INTENSIVE CARE UNIT. CONTINUOUS INVASIVE ARTERIAL BLOOD PRESSURE MONITORING SURPASSESS THE NONINVASIE INTERMITTENT BLOOD PRESSURE MONITORING BY ITS ABILITY TO A GIVE A REAL TIME BLOOD PRESSURE MONITORING.ANY ANTICIPATED PHARMACOLOGIC OR MECHANICAL CARDIOVASCULAR MANIPULATION,REQUIREMENT OF FREQUENT BLLOD SAMPLING AND SUPPLEMENT THE DIAGNOSTIC INFROMATION FROM ITS ARTERIAL WAVEFORM. TRADITIONALLY THE CANNULATION HAS BEEN PERFORMED USING ANATOMIC KNOWLEDGE AND PULSE PALPATIONAS A GUIDE TO PLACEMENT.HOWEVER PATIENTS REQUIRING ARTERIAL LINES MAY BE OBESE OR EDEMATOUS OR HAVE FEEBLE PULSESECONDARY TO HYPOTENSION AND ALSO THE CATHETER MAY NOT BE PASSED SUCCESSFULLY  INTO THE ARTERY DESPITE APPARENT GOOD BLOOD RETURN AFTER INITIAL PUNCTRE OR THE ARTERY MAY DEVEOP SPASM. AFTER A FAILED ATTEMPT THUS MAKING BLIND PALPATORY TECHNIQUE A DIFFICULT ONE. THIS STUDY IS AN ATTEMPT TO COMPARE THE TRADITIONAL PALPATORY TECHNIQUE WITH THE USG GUIDED TECHNIQUE IN TERMS OF CANNULATION TIME,THE NUMBER OF ATTEMPTS, CHANGE TO OTHER SITE OR ARTERY OR ALTERNATIVE PROVIDER. 
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