In today’s world, individuals are constantly exposed to stressors, making it difficult to avoid the impact of chronic stress. This increased exposure contributes to the rising incidence of stressrelated disorders such as depression, anxiety, and various neurodegenerative diseases. A systematic review conducted an integrative analysis of longitudinal and cross-sectional studies, revealing an inverse association between stress and quality of life. Furthermore, a separate review investigated the consequences of psychological stress on the aging process, concluding that it may impede healthy aging. Individuals with mental health diagnoses may experience stigma and social discomfort, leading to decreased help-seeking behaviours. This manifests as avoidance of healthcare professionals, staff, and service users. Additionally, it can hinder disclosure of information, limit question-asking and responding, and discourage complaints. 

Non-adherence to prescribed medications, particularly in public settings like educational institutions (colleges) and workplaces, presents a significant challenge. Research has been continuing to find a better alternative. This calls for the need to develop newer therapeutic strategies. Despite advancements in therapies and medications, achieving optimal treatment outcomes for stress-related conditions remains a challenge. Limited access to and high cost of psychotropic medications for patients continues to be a significant barrier to effective treatment. Therefore, exploring strategies to modulate an individual’s stress response is crucial. Plant extracts offer a promising avenue for mitigating the detrimental effects of stress, potentially serving as complementary or alternative approaches to existing medications and therapies.

 Investigational products containing ingredients like Rosemary (Rosemarinic acid and carnosic acid) and Ashwagandha (Withanolide aglycone and Withanolide glycosides) have the potential to calm the mind, reduce brain hyperactivity, and improve mood and anxiety. Rosemary and Ashwagandha possess well-documented ethnopharmacological and preclinical evidence supporting their potential anxiolytic, mood-enhancing, and cognitive-enhancing effects. Rosemary has demonstrated promising clinical effects on mood, learning, memory, pain, anxiety, and sleep. Ashwagandha, a renowned adaptogen, boasts a rich historical tradition and a wide array of purported health benefits, including stress reduction.

 Given their individual and potentially synergistic mechanisms of action, a combination of these botanical agents may offer a more comprehensive and effective approach to mitigating stress,anxiety, and associated symptoms. While promising preclinical and limited clinical data exist, further rigorous investigations are warranted to establish the efficacy and safety of this botanical combination in managing stress, anxiety, and improving mood in adult populations.