1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   Response -  Analytic Code
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [veena.v@cmcvellore.ac.in].
   


6. For how long will this data be available start date provided 24-03-2025 and end date provided 23-04-2026?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - nil

Striae distensae (SD) or stretch marks are linear atrophic dermal scars covered with flat atrophic epidermis. This study aims at comparing the efficacy and safety of Fractional CO2 laser alone and in combination with topical Tretinoin 0.05% gel in the treatment of striae distensae in skin of colour Fitzpatrick skin phototypes III, IV, V and VI.

As, there are not many studies that compares fractional CO2 laser versus topical tretinoin 0.05% gel for striae distensae in Indian skin types, our study will be usefull in comparing the efficacy of both these modalities in the treatment of striae distensae.

All patients with SD visting our Dermatology, Venereology and Leprosy/Cosmetic Dermatology OPD seeking treatment for the same will be enrolled in our study after informed consent. Patients will be examined and extent of striae will be assessed. In patients having multiple sites of involvement, the site of maximum cosmetic concern over the abdomen  will be selected for intervention. Abdomen will be divided into two halfs keeping the longitudinal midline as the center. The lesions on the side to be treated  with Fractional CO2 laser will be randomly selected by using a chit method. The other side will be treated with topical tretinoin 0.05 % gel. The Tretinoin gel will be continued on a daily basis at night. A total of three laser sessions will be done with an interval of 1 month duration. Post procedure white soft paraffin will be recommended for daily application in the morning over the sites of treatment.  Patients will be assessed immediately post treatment for any redness, burning, pain or discomfort. They will also be followed up in the subsequent visits for any untoward complications like post inflammatory hyperpigmentation, infection, persistent erythema, ulcers, scarring and keloid formation. Photographs will be taken at baseline, before each session and at the end of 1 month after the last session. 

In our study, the Global aesthetic improvement scale will be used for comparing the photographs at baseline with the final photographs 1 month after the last laser session by a single investigator. The patient satisfaction scores will be done 1 month after the last laser procedure. The width of the striae will also be assessed using dermoscopy prior to initiation of treatment and at 1 month after the last session.