This study explores the association between nutritional deficiencies and malocclusion in tribal populations, with a specific focus on adolescents aged 15–18 years from the Melghat region. Malocclusion, a common dental issue, is especially prevalent in underserved tribal areas due to poor nutrition, limited healthcare access, and lack of awareness. The introduction outlines how deficiencies in key nutrients like calcium, vitamin D, iron, and B12 negatively affect dental and skeletal development, contributing to various forms of malocclusion such as crowding and bite issues. The primary research question investigates the relationship between these deficiencies and malocclusion prevalence. The literature review presents studies that have linked poor dietary intake and limited healthcare to higher malocclusion rates in tribal populations. However, most research to date lacks empirical data, focuses on general populations, or fails to explore specific nutrient-related correlations. This highlights a research gap that this study aims to fill.The aim of the study is to assess the relationship between specific nutritional deficiencies and malocclusion in Melghat’s tribal adolescents. Objectives include evaluating the prevalence of both nutritional deficiencies and malocclusion, as well as raising awareness and understanding their connection.Methodology, Design Cross-sectional study in collaboration with the Public Health Centre in Tembursonda, Sample 185 tribal adolescents 15–18 years, selected through convenience sampling, Inclusion/Exclusion Criteria Focuses on tribal status, age, residency, and health status to ensure reliable results.Nutritional Assessment (via blood tests): Iron, Calcium,Vitamin B12,Vitamin D. Malocclusion Assessment Based on Angle’s classification Class I, II, III and Dental Aesthetic Index.Trained dentists will assess additional traits like crowding, spacing, and bite issues.