Prameha is described as one of the Ashtamahagada  in ayurveda samhita. Prameha which has been a global problem is described in ancient Indian classics like Charak Samhita, Sushruta Samhita, Ashtanga Sangraha, Ashtanga Hridaya, Yogratnakara etc. It’s described thoroughly as etiology, pathogenesis, prognosis, complications, it’s management. The Indian ancient samhitas also describe the relationship of dietary, lifestyle, environment and genetic factors. The Prameha which was described as mahagada in ancient time is still difficult to treat in 21st century.

The pathogenesis of Prameha indicates that vitiated Three Doshas (vata, pitta, kapha)  and Ten Dushyas (rasa, rakta, mansa, meda, majja, shukra, lasika, vasa and ooj) are responsible for development of Prameha according to Ayurveda. The main dosha is vitiated kapha dosha is responsible in the samprapti of Prameha (kaphakrut ch sarvam). Acharya described 20 types of Prameha on the basis of predominance of dosha and appearance of mutra(urine).

In this era of globalization, lifestyle is changing everyday. The living habits, eating habits of people are changing day to day. Irregular food intake, lack of exercise, excessive stress, work life imbalance, disturbed sleep pattern eventually affect the metabolism of human body. These give rise to lifestyle disorders. Diabetes is characterised by hyperglycemia i.e. raised blood glucose level developing the symptoms like polydipsia, polyphagia, polyuria, nocturia, Fatigue etc. The prevalence of diabetes in India in adults is estimated to be 11.3%. 

Ayurveda samhitas have such wonderful formulations. The kalpa varadarvyadi ghanvati is described in sharangdhara samhita. The contents of this kalpa are 1)vara(triphala), 2)darvi(daruharidra), 3)musta, 4)deodaru.

This combination of drugs mentioned above helps in sampraptibhanga of prameha and is easy to available. Taking all this consideration the study is taken up entitled “A controlled clinical study to evaluate the efficacy of ‘Varadarvyadi Ghanavati’ in the management of Prameha with special reference to Type 2 Diabetes Mellitus.

Scope of study :- 

Though we have the tremendous medicines, modern medicine shows limitations in the management of metabolic diseases. Hence we are moving towards ayurvedic approach.

In India, prevalence of diabetic population is high. Diabetes mellitus hampers cellular components of organ or entire system. Diabetes is going to be a major health issue due to its serious complications. In the management of DM with modern medical science, we have to face related complications like GI upset, nausea, diarrhea, lactic acidosis etc. Here, ayurveda provides as an adjuvant therapy to modern medicine. Thus, there is need of clinical research in getting a hold on this disease not only to achieve good glycemic control but also to treat the root cause.

Group A: Study group - 45 patients will be administered Varadarvyadi Ghanavati along with Metformin.

Group B: Control group - 45 patients will receive only Metformin.

Blood CBC, ESR, BSL fasting and PP, Liver Function and Renal Function Test, Lipid Profile to exclude any Pathology.

Glycosylated Hemoglobin(HbA1C) test will be estimated before and after treatment.

The work will be summarized to make final conclusions.

Observations of results will be concluded with statistical analysis under the heading ‘Conclusion’ with explanation at the end of whole research.

? Changes in subjective by ’Varadarvyadi Ghanavati’ towards reduction in previous severity.

? Changes in Glycosylated Hemoglobin(HbA1C) by ’Varadarvyadi Ghanavati’ towards reduction of Fasting and Post Prandial Blood Sugar Level.