This six-month cross-sectional observational study aims to assess the quality of life (QOL) in children with epilepsy (CWE) and explore the influence of sociodemographic factors on their overall well-being. The study is conducted at a tertiary care teaching hospital in coastal Karnataka, with participants aged 4–18 years who have been diagnosed with epilepsy and on treatment for at least six months. Children with intellectual disabilities, developmental delays, or other chronic conditions are excluded. Using non-probability sampling, data will be collected through the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55), which evaluates cognitive, emotional, social, and physical aspects of QOL. The study aims to assess the quality of life in CWE, examine the relationship between sociodemographic factors (such as gender, parental education, and socioeconomic status) and QOL, and identify key predictors of QOL that can guide clinical and social interventions for improving their overall well-being. Statistical analysis will be performed using Spearman correlation, Chi-square tests, t-tests, ANOVA, and multivariable regression to determine significant associations. Ethical considerations include Institutional Ethics Committee (IEC) approval, ensuring patient confidentiality and adherence to ethical guidelines. The findings from this study are expected to provide valuable insights into the social determinants of QOL in CWE, helping develop targeted interventions, healthcare policies, and support systems for affected children and their families in India.