CTRI

Periodontitis is described as an inflammatory process, initiated by plaque biofilm that leads to loss of periodontal attachment to the root surface and adjacent alveolar bone which ultimately results in bone loss. The inflammatory and immune responses to the bacteria that colonize the periodontal and associated tissue creates a bidirectional series of host- microbial interactions. While the primary etiologic agent is predominantly gram-negative bacteria within the sub gingival biofilm, the majority of periodontal tissue destruction is caused by an inappropriate host response to those microorganisms and their products more specifically a loss of homeostatic balance between proteolytic enzymes and their inhibitors and reactive oxygen species and the antioxidant defence systems resulting in generation of free radicals leading to decrease in the anti- oxidant defence.

Melatonin is an indoleamine hormone produced by the pineal gland that governs the human bodyâ€™s circadian rhythm and biological clock, plays an important role in the control of periodontal disease due to its significant anti-inflammatory and anti-oxidant property by directly neutralizing the highly destructive reduced oxygen species generated by oxygen derived free radicals. And it can also block reduced oxygen species produced by the superoxide dismutase therefore playing an important role in regulatory bone resorption process. It has ability to bind metals suppresses bacteria development in invitro which is linked to periodontitis. Melatonin levels can fluctuate in periodontitis due to oxidative stress and bacterial invasion caused by loss of homeostatic balance between proteolytic enzymes and their inhibitors^.

Full mouth disinfection is one of the nonsurgical treatment options for periodontitis, in which the bacterial biofilm is removed, reducing the bacterial burden and hence the rate of formation of free radicals.

Saliva as a mirror of oral and systemic health is a valuable source of clinically relevant information because it contains biomarkers and also bacteria specific for the unique physiologic aspects of periodontal disease. Hence interest in saliva as a diagnostic and a medium for prognosticate periodontal treatment outcomes in escalating due to its advantages over other diagnostic biofluids as it is readily available which makes the collection process fairly straight forward with no potential for cross contamination.

Although the potential therapeutic effect of melatonin in periodontitis has been well documented in various in vitro, animal studies and clinical trials, the relation ship between the periodontal status and the influence of periodontal treatment on salivary melatonin and levels of Tannerella forsythia in saliva is still conclusive, the present study was aimed to evaluate the effect of full mouth disinfection on salivary melatonin levels of Tannerella forsythia in saliva in patients with chronic periodontitis and also to explore the possible correlations between clinical parameters, salivary melatonin levels and levels of Tannerella forsythia in saliva.