The classical reference of Amlapitta are from Kashyapa Samhita ,Yogaratnakara and Bhava-prakasha and Madhav Nidana,.In Amlapitta the root cause is Agnimandya and formation of Aama .Treatment of Amlapitta  : Agnideepaka and Aamapachaka drugs are used .Tikta Rasapradhana drugs are commonly Aamapachaka & Agnideepaka acts on annavaha srotas. All diseases are caused by Mandagni (weak digestive fire), which negatively affects the samana and udana vayu, as both vayu are responsible for proper digestion.The excessive consumption of Amla (sour), Katu (spicy), Ushna (hot), and Viruddhashana (incompatible food combinations) can lead to an aggravation of Pitta dosha. Normally, Pitta has a Katu rasa (spicy taste), but when it is converted into Amla rasa (sour taste), it results in Amlapittam. Diagnosis is done based on Rome IV criteria.

Trial drug : Simhasyadi ghana vati told in Chakradatta / Amlapitta adhikara.The ingredients are Vasa(Adatoda vasica ), Guduchi(Tinospora cardifolia ) and Brihati (Solanum indicum). It is indicated in Amlapitta,svasa,kasa and chardi expected to have effectiveness in Functional dyspepsia (Amlapitta). The mode of action of this yogam is Pittashamaka and Tridoshagna property due to its kashaya rasa , madura vipaka , laghu , snigha guna ,ushna veerya. It contains chemical constituents such as pyrroloquinazoline , glucosides which helps in healing the gastric mucosa.