·       Osteoarthritis is a common degenerative joint disease causing pain, swelling, and stiffness, primarily affecting knees, hips, spine, and hands. It limits mobility and daily activities, often termed as "wear and tear" arthritis. The high prevalence in modern times leads to joint disability. Schussler’s theory suggests disease results from disturbed molecular motion of cell salts in tissues, rectifiable by administering small quantities of the same mineral salts and Loss of Calcarea Fluor in the system can lead to the development of hard, knotty exudations on bone surfaces and inflammation of the knee joint with associated joint cracking so, Biochemic salt supplementation is proposed to prevent knee osteoarthritis progression.

·       A non-randomized study will be conducted to assess the effect of calcarea fluor 6x in osteoarthritis of knee. The study will investigate the potential benefits of Homoeopathy in managing osteoarthritis of knee. The study will enroll 42 patients and will be conducted at the Jawaharlal Nehru Homoeopathic Medical College, Parul University, Vadodara, Gujarat, India.

·       Case taking according to Dr. Hahnemann’s Organon of Medicine guidelines, Diagnosed of knee osteoarthritis using ACR criteria, necessary investigations as per case requirements, Assessment and evaluation of osteoarthritis of knee would be done using the self-made questionnaire based on Womac Index and treatment with Calcarea Fluor in 6X potency, and follow-up every fifteen days or as and when required.