FULL DETAILS (Read-only)  -> Click Here to Create PDF for Current Dataset of Trial
CTRI Number  CTRI/2025/06/088311 [Registered on: 05/06/2025] Trial Registered Prospectively
Last Modified On: 05/06/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   Role of homoeopathy in conjunctivitis 
Scientific Title of Study   Study on effectiveness of homoeopathic treatment in conjunctivitis 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Dharmi Anilbhai Khaniya 
Designation  PG Scholar 
Affiliation  Rajkot Homoeopathic Medical College 
Address  Department of practice of medicine, Rajkot Homoeopathic Medical College, behind jainath complex, makkam chowk, Rajkot Rajkot GUJARAT 360002 India

Rajkot
GUJARAT
360002
India 
Phone  8511454164  
Fax    
Email  dharmikhaniya@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Shilendra Bhamar 
Designation  Professor &HOD Department of practice of medicine  
Affiliation  Rajkot Homoeopathic Medical College 
Address  Department of practice of medicine, Rajkot Homoeopathic Medical College, behind jainath complex, makkam chowk, Rajkot Rajkot GUJARAT 360002 India

Rajkot
GUJARAT
360002
India 
Phone  9131331597  
Fax    
Email  shailendra.bhamar17970@paruluniversity.ac.in  
 
Details of Contact Person
Public Query  
Name  Dr Dharmi Anilbhai Khaniya 
Designation  PG Scholar 
Affiliation  Rajkot Homoeopathic Medical College 
Address  Department of practice of medicine, Rajkot Homoeopathic Medical College, behind jainath complex, makkam chowk, Rajkot Rajkot GUJARAT 360002 India

Rajkot
GUJARAT
360002
India 
Phone  8511454164  
Fax    
Email  dharmikhaniya@gmail.com  
 
Source of Monetary or Material Support  
Rajkot homoeopathic medical college, Near ICICI Bank, Makkam Chowk, Gondal Road, Rajkot 
 
Primary Sponsor  
Name  Rajkot Homoeopathic Medical college 
Address  Department of practice of medicine, Rajkot Homoeopathic Medical College, behind jainath complex, makkam chowk, Rajkot Rajkot GUJARAT 360002 India 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
nil  nill 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Dharmi Khaniya  Rajkot Homoeopathic Medical College  Department of Practice of Medicine, Rajkot Homoeopathic Medical College, behind jainath complex, makkam chowk, Rajkot Rajkot GUJARAT 360002 India
Rajkot
GUJARAT 		 8511454164

dharmikhaniya@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Instutional Ethics Committe for Human Research Rajkot Homoeopathic medical college , Parul university Gujarat  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: H109||Unspecified conjunctivitis,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Individualized Homoeopathic Medicine   Individualized Homoeopathic Medicine selection is based on the Totality of Symptoms for each case as their simillimum. o Mode of administration : All medications will be administered orally. Selection of potency , dose and repetition: Individualized medicine will be prescribed in 30, 200, 1M potency. Selection of dosage , potency and repetition will be according to susceptibility of patient and principles of organon of medicine  
Comparator Agent  Not applicable  Not applicable 
 
Inclusion Criteria  
Age From  0.00 Day(s)
Age To  70.00 Year(s)
Gender  Both 
Details  Patients; age group from infants to old age, both sexes and all socio – economic status will be taken for study. 
 
ExclusionCriteria 
Details  Cases with, systemic diseases associated with dry eye will be excluded.
Cases with irregular follow-ups will be excluded.
Patient taking other therapeutic measures for conjunctivitis or any other disease.
 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
There will be some improvement after prescribing homoeopathic medicines.   There will be some improvement after prescribing homoeopathic medicines after 3 days , 5 days, 1 week. 
 
Secondary Outcome  
Outcome  TimePoints 
1)Cured – Sensation of wellbeing physically with disappearance of all the symptoms of conjunctivitis for which the patient approached without recurrence within period of study.
2)Improved – Decrease in intensity and/or frequency of presenting complaints in conjunctivitis with feeling of wellbeing.
3)Not improved – No change in presenting complaints. 		 There will be some improvement after prescribing homoeopathic medicines after 9 months.  
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2/ Phase 3 
Date of First Enrollment (India)   01/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

1

NEED FOR THE STUDY:

Conjunctivitis is a commonly encountered condition in ophthalmology clinics throughout the world. In the management of suspected cases of conjunctivitis, alarming signs for more serious intraocular conditions, such as severe pain, decreased vision, and painful pupillary reaction, must be considered. Additionally, a thorough medical and ophthalmic history should be obtained and a thorough physical examination should be done in patients with atypical findings and chronic course. Concurrent physical exam findings with relevant history may reveal the presence of a systemic condition with involvement of the conjunctiva. Viral conjunctivitis remains to be the most common overall cause of conjunctivitis. Bacterial conjunctivitis is encountered less frequently and it is the second most common cause of infectious conjunctivitis. Allergic conjunctivitis is encountered in nearly half of the population and the findings include itching, mucoid discharge, chemosis, and eyelid edema. Long-term usage of eye drops with preservatives in a patient with conjunctival irritation and discharge points to the toxic conjunctivitis as the underlying etiology. Effective management of conjunctivitis includes timely diagnosis, appropriate differentiation of the various etiologies, and appropriate treatment.[1]

 

Homoeopathy has been identified for more than 200 years ago as an holistic medical Technique which provides mild methods for treating number of illness including Conjunctivitis also reffered to as “Pink Eye”. In conjunctivitis Homoeopathic remedies are Quite useful as they know how to deal with ocular discharges, Oedema, redness and a Scratchy feeling in the eyes. Homoepathic remedies if taken at early, they shorten the Duration of the illness. They are free of risk and have no favourable side effects [2]

Epidemiology

The occurrence of conjunctivitis depends on various factors such as age, gender, and time of the year. In the emergency department, cases of acute conjunctivitis show a bimodal distribution. The first peak is observed among children under 7, with the highest incidence between 0 and 4 years. The second peak occurs at 22 years in women and 28 years in men. Though overall rates of conjunctivitis diagnosed in the emergency Department are slightly higher in women than in men, seasonality also plays a role in the presentation and diagnosis of conjunctivitis. Across all age groups, there is a peak incidence of conjunctivitis in children 0 to 4 years in March, followed by other age groups in May.

Regardless of changes in climate or weather patterns, seasonality is consistent for all geographic regions, as described in a nationwide emergency department study. Allergic conjunctivitis is the most common cause of conjunctivitis, affecting 15% to 40% of the population, and is often observed in spring and summer. Bacterial conjunctivitis rates are highest from December to April. Allergic conjunctivitis is considered the most common allergic ocular disease, affecting 15% to 20% of the population, with seasonal and perennial types.

 

Conjunctivitis prevalence and incidence may change Depending on the underlying cause, and it may be Influenced by the age of the patient as well as the time of Year.

Infective Conjunctivitis:

 The incidence of infectious conjunctivitis is 80,000 per 100,000 episodes of acute conjunctivitis. The incidence of infectious conjunctivitis brought on by An adenovirus is roughly 65000–90000 cases per 100,000 cases of viral conjunctivitis. There are 1300 to 4800 cases of acute bacterial Conjunctivitis, which is brought on by the herpes Simplex virus.

Neonatal Conjunctivitis:

Neonatal conjunctivitis, also known as ophthalmia Neonatorum, continues to cause the blindness of about 10,000 Infants each year in the global population.

Allergic Conjunctivitis:

According to estimates, there are 6,000 to 40,000 cases of Allergic conjunctivitis for every 100,000 people[3]

Anatomy

The conjunctiva is a translucent mucous membraneWhich lines the posterior surface of the eyelids andAnterior aspect of eyeball. The name conjunctiva(conjoin: to join) has been given to this mucousMembrane owing to the fact that it joins the eyeballTo the lids. It stretches from the lid margin to theLimbus, and encloses a complex space calledConjunctival sac which is open in front at the

Palpebral fissure.

Parts of conjunctiva

Conjunctiva can be divided into three parts

1.      Palpebral conjunctiva. It lines the lids and can be Subdivided into marginal, tarsal and orbital Conjunctiva.

i.                    Marginal conjunctiva extends from the lid margin To about 2 mm on the back of lid up to a shallow Groove, the sulcus subtarsalis. It is actually a Transitional zone between skin and the conjunctiva Proper.

ii.                  Tarsal conjunctiva is thin, transparent and highly Vascular. It is firmly adherent to the whole tarsal Plate in the upper lid. In the lower lid, it is Adherent only to half width of the tarsus. The Tarsal glands are seen through it as yellow streaks.

     Iii .Orbital part of palpebral conjunctiva lies loose between the tarsal plate and fornix

 

2.      Bulbar conjunctiva. It is thin, transparent and lies Loose over the underlying structures and thus can be Moved easily. It is separated from the anterior sclera By episcleral tissue and Tenon’s capsule. A 3-mm ridge Of bulbar conjunctiva around the cornea is called Limbal conjunctiva. In the area of limbus, the Conjunctiva, Tenon’s capsule and the episcleral tissue Are fused into a dense tissue which is strongl Adherent to the underlying corneoscleral junction. At the limbus, the epithelium of conjunctiva becomes Continuous with that of cornea.

 

3.      Conjunctival fornix. It is a continuous circular Cul-de-sac which is broken only on the medial side By caruncle and the plica semilunaris. Conjunctival Fornix joins the bulbar conjunctiva with the palpebral conjunctiva. It can be subdivided into superior, inferior, medial and lateral fornices.[4]

 

In conventional system of medicine disease is suppressed and it is also can create various complication, but in homoeopathic system it is almost always possible to avoid antibiotics and surgery. homoeopathy improve tendency to have recurrent infections or allergy, A great advantage that homoeopathic treatment offers along with the treatment of conjunctivitis is that it also strengthens immune system , thereby preventing from recurrent attacks, that’s why I took up this challenge through this study to confirm the role of homoeopathy in case of conjunctivitis.









 

 

 
 
Close