Radiation induced oral mucositis (RIOM) is a common health problem among the Head and neck cancer subjects undergoing Radiotherapy. Paucity of good quality trials involving efficacious agents evaluating the self applied, less toxic and more efficacious formulations needing least resources and less technique sensitivity over professionally applied  treatment modalities needs concerns. Novelity: VG111 (Sepil), is a novel natural formulation containing extract of Sesamum indicum L., Azadirachta indica, Honey bee wax and others which is developed at PGIMER, Chandigarh  as an ideal wound healing product that acts by lowering IL-6 and TNF-α levels. Objectives: To compare the effectiveness of VG111 mouthwash over benzydamine hydrochloride mouthwash in reducing incidence, progression and severity of RIOM among RT subjects of oral cavity and oropharyngeal cancer and changing the salivary inflammatory mediators and reduction of adverse effects due to RT like dysphagia, oral pain, significant weight loss and QoL. This study is randomized, triple blinded, two arm, parallel clinical trial comparing the effectiveness the novel VG111(Sepil) mouthwash -10ml of aqueous extract of solution for two to four times daily and Benzydamine Hydrochloride(0.15%) four to eight times daily and to be started one week before radiotherapy till 7 weeks or 2 weeks after completion in 124 patients that will be conducted in India. The primary outcome will be the assessment of incidence, progression and severity of Radiation Induced Oral mucositis through WHO Oral toxicity scale  and Oral mucositis assessment scale(OMAS). The secondary outcome will be the change in salivary inflammatory mediators at baseline third and seventh week of interventions. The indigenously prepared solutions can prove to be an effective RIOM preventive regimen that can be implemented sustainably in developing nations due to self applied and other properties.