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CTRI Number  CTRI/2025/02/081173 [Registered on: 24/02/2025] Trial Registered Prospectively
Last Modified On: 16/09/2025
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Other 
Public Title of Study   Etiopathogenesis of Adenoid Hypertrophy in Ayurvedic aspect 
Scientific Title of Study   An Observational Study to Assess the Etiopathogenesis of Adenoid Hypertrophy in Ayurveda 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr SARANYA P 
Designation  PG scholar 
Affiliation  Government Ayurveda College ,Pariyaram,Kannur, Kerala 
Address  Department of Roganidana Government Ayurveda College Pariyaram Kannur Kerala India

Kannur
KERALA
670503
India 
Phone  9539824064  
Fax    
Email  saranyac927@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr FARSEENA K 
Designation  Assistant Professor 
Affiliation  Government Ayurveda College, Pariyaram,Kannur 
Address  Department of Roganidana Government Ayurveda College Pariyaram Kannur Kerala

Kannur
KERALA
670503
India 
Phone  9995744141  
Fax    
Email  drfarziaman@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr SARANYA P 
Designation  PG scholar 
Affiliation  Government Ayurveda College ,Pariyaram,Kannur 
Address  Department of Roganidana Government Ayurveda College Pariyaram Kannur Kerala

Kannur
KERALA
670503
India 
Phone  9539824064  
Fax    
Email  saranyac927@gmail.com  
 
Source of Monetary or Material Support  
Government Ayurveda College, Pariyaram,Kannur, Kerala, India PIN-670503 
 
Primary Sponsor  
Name  Government Ayurveda College,Kannur 
Address  Pariyaram Kannur 670503 Kerala 
Type of Sponsor  Other [Government Ayurveda College] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Saranya P  Government Ayurveda College Hospital,Kannur  Roga nidana department Room number-7
Kannur
KERALA 
9539824064

saranyac927@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee-Government Ayurveda College,Kannur  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:J352||Hypertrophy of adenoids. Ayurveda Condition: KANTHAGATAROGAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
 
Inclusion Criteria  
Age From  5.00 Year(s)
Age To  12.00 Year(s)
Gender  Both 
Details  Diagnosed cases of children with Adenoid Hypertrophy aged between 5-12 years of both gender attending OPD and IPD of Government Ayurveda College, Kannur  
 
ExclusionCriteria 
Details  Children with serious systemic diseases
Children taking medicines for Asthma
Children with Epistaxis
Children with serious Psychiatric illness
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To propose a possible Samprapthi of Adenoid Hypertrophy  18 Months 
 
Secondary Outcome  
Outcome  TimePoints 
Assesment of nidana,dosha,dhatu,agni,prakruthi in patients with Adenoid Hypertrophy  18 months 
 
Target Sample Size   Total Sample Size="86"
Sample Size from India="86" 
Final Enrollment numbers achieved (Total)= "86"
Final Enrollment numbers achieved (India)="86" 
Phase of Trial   N/A 
Date of First Enrollment (India)   05/03/2025 
Date of Study Completion (India) 23/06/2025 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details
Modification(s)  
AYURVEDIC MANAGEMENT OF PALMOPLANTAR PSORIASIS:AN EVIDENCE BASED CASE REPORT Saranya P1*, PM Madhu2, Farseena K2 * 1PG Scholar, 2Assistant Professor, Department of Roganidana, Government Ayurveda College, Kannur, Kerala International Journal of Ayurveda and Pharma Research https://doi.org/10.47070/ijapr.v13i5.3728 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary
Modification(s)  

The study entitled An observational study to assess the etiopathogenesis of Adenoid Hypertrophy in Ayurveda” was conducted to analyse the nidana, dosha, dhathu, srothas, and agni involved in the pathogenesis of the disease. Adenoid Hypertrophy is a condition characterised by the abnormal enlargement of the adenoid tissue, located in the nasopharynx, which can lead to nasal obstruction, mouth breathing, snoring, recurrent infections, and other complications. The prevalence of the disease is increasing, and the complications that arise due to the condition are also wide-ranging. Hence, there is a need to analyse the pathophysiology in Ayurvedic standards to study the disease completely, as samprapthi vighatana is chikitsa.

A total of 86 clinically diagnosed cases of Adenoid Hypertrophy were included in the study. Data collection was done using a structured proforma which included demographic details, family history, clinical features observed in the patients, vital data and specific Ayurvedic assessments. The Ayurvedic parameters studied included Prakruthi assessment, assessment of nidanas, agni status,dosha dusthti lakshanas, dhathu involvement, and srothodusthi. Statistical analysis was carried out using descriptive methods.

The results revealed that the majority of participants were indulging in the consumption of kapha-vardhaka as well as agni-mandhyakara ahara and vihara, which are considered contributory factors in the pathogenesis of the disease. Most of the participants exhibited clinical features suggestive of vatha-kapha pradhana dosha dushti. Among the dhathus, mamsa dhathu and rasa dhathu were identified as the primary factors involved in the disease causation. With regard to srothas, the study showed the involvement of pranavaha srothas, rasavaha srothas, mamsavaha srothas, and pureeshavaha srothas in the pathogenesis. Furthermore, evidence of agnidushti was observed in the majority of cases, indicating impairment in digestive and metabolic functions. Interestingly, certain Krimi lakshanas were also traced in a considerable proportion of participants. By analysing the above factors, a possible samprapthi of the disease was formulated, with special emphasis on identifying and highlighting the samprapthi ghatakas involved.


 
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