experience numerous metabolic problems, including primary hypothyroidism. Hypothyroidism is one of the burning issue now a days. An unusually low thyroid hormone level is one of the symptoms of hypothyroidism. It happens when the thyroid gland does not produce enough thyroxine. Each organ in the body may be impacted by thyroxine’s control over how the body uses energy. Thyroxine deficiency causes the body’s functions to slow down. It affects nearly every bodily function, therefore maintaining a healthy level of thyroid hormone is essential for good health. The prevalence rate of hypothyroidism in Mumbai is 9.45%. Thyroid disease affects women more often than men and affects roughly 5% of the population. Womens are affected approximately six time more frequently than men. Ayurveda states that the pathophysiology of hypothyroidism is mostly caused by agni’s improper activity. It can be correlated to the concept of mandagni in ayurveda. The pathogenesis process is eventually shown by abnormal jatharagni functioning, which then affects dhatwagni and, ultimately, results in the disease condition.

Varunadi Gutika is a combination of 09 drugs, which are Varun, Bruhati, Kanthakari, Chitrak, Bilva, Shobhanjan, Shatavari, saireyak, karanja. All these drugs have Ushna, Tikshna, Deepana, Pachana and Grahi properties therefore it will reduce the symptoms of hypothyroidism comparing to ’mandagni’

For the treatment of primary hypothyroidism, an efficient pharmaceutical preparation is required. As the hormone replacement therapy is only available way to treat the condition. There is flaw in this conventional treatment because it required prolonged use. With the chronicity of the disease, the gland functioning never improves, instead they become more and more inactive. Taking above in consideration, I have chosen my synopsis under title, “An Open Randomised Controlled Clinical Study to evaluate the efficacy of Varunaadi gutika as an adjuvant therapy with Levothyroxine in the management of primary hypothyroidism."

Group A: Study group -30 patient will be administered Varunadi gutika along with

Levothyroxine.

Group B: Control group-30 patient will receive only Levothyroxine.

CBC, ESR, BSL fasting and PP, Liver Function and Renal Function Test, Lipid Profile to exclude any Pathology.

Thyroid function test , BSL and Lipid profile will be estimated before and after treatment.

The work will be summarized to make final conclusions Observations of results will be concluded with statistical analysis under the heading ‘Conclusion’ with explanation at the end of whole research.

• Changes in subjectives by ’Varunadi Gutika’ towards reduction in previous severity.

• Changes in Thyroid profile by ’Varunadii Gutika’ towards reduction of Sr.TSH in previous high levels.

• Effect of ’Varunadi Gutika’ could be more than the effect of Tab.Levothyroxine without any adverse effects.