Breast cancer is the most commonly diagnosed malignancy and the leading cause of death among women worldwide. Breast cancer alone is responsible for 30% ⁽¹⁾ of newly diagnosed cancer cases in women and there is a probability that one in eight women will develop breast cancer in her lifetime, while 14% of cancer-related deaths are attributed to it. More than 100,000 patients are estimated to be diagnosed with breast cancer every year in India which depicts the disease burden. Breast cancer has been rising steadily over the last decade or so, and is now the most common cancer in women in India, way ahead of cervical cancer (which was the leading cancer previously). Breast cancer treatment is highly effective, especially when the disease is identified in early stage. Treatment of breast cancer often consists of a combination of surgery, radiation therapy and systemic therapy (hormonal therapy, chemotherapy and/or targeted biological therapy). This multi-modality treatment of breast cancer is also associated with certain acute and late adverse events affecting the quality of life of the patient.Hence, I am conducting present study to determine the Patient Reported Outcomes of acute toxicities and its overall affect on quality of life in this group of patients.