This open-label, single-arm interventional clinical trial aims to evaluate the anti-aging efficacy and safety of a topical Ashwagandha moisturizing cream in reducing the appearance of fine lines and wrinkles among healthy volunteers. Thirty participants will apply the Ashwagandha cream daily over a 16-week period, with assessments conducted at baseline (Week 0), and at Weeks 4, 8, 12, and 16. The primary objective of the study is to assess the cream’s efficacy in reducing wrinkle appearance and fine lines, with secondary objectives including evaluation of tolerability, safety, and overall improvement in skin health as reported by participants.

Clinical wrinkle assessment will be conducted using Standard Wrinkle Scales, focusing on specific facial areas: the Crow’s Feet Wrinkle Scale (CFWS) for the lateral eye area, Forehead Wrinkle Severity Scale (FWSS) for forehead lines, Nasolabial Fold Wrinkle Scale (NLFS) for nasolabial wrinkles, and Global Fine Line Scale (GFLS) for general fine lines. High-resolution digital imaging will be used to objectively record and measure wrinkle depth and fine line counts. Participants will also complete a Self-Assessment Questionnaire evaluating various skin parameters, including hydration, moisture retention, wrinkle reduction, elasticity, firmness, texture, radiance, and overall satisfaction. A Global Tolerability Assessment will be conducted at each visit to monitor safety and participant comfort.

This study is designed to provide insights into the efficacy and tolerability of Ashwagandha moisturizing cream as a topical anti-aging solution, with clinical and subjective measures used to assess its potential in enhancing skin health and appearance.