INTRODUCTION: Dengue is a fast emerging, outbreak-prone and mosquito-borne viral fever. The incidence of Dengue is increasing in recent years with repeated outbreaks from many States and newer areas. At present, except Ladakh all the States and Union Territories are reporting Dengue cases1 Dengue is viral infection transmitted by mosquitoes. Dengue viruses are flaviviruses related to yellow fever virus and Japanese encephalitis virus. There are four serotypes, infection with one serotype does not induce solid immunity to the others, and individuals may suffer from dengue more than once. 2 Transmission is by day-biting of Aedes aegypti mosquitoes. It is not transmitted directly between humans. Ayurvedic view Jwara is the most common independent disease entity. It can also be found as a symptom of several other diseases too. Jwara deserves to be described first being the foremost of all Somatic diseases. It is also recognized as the most important cause of death.3It is a condition in which the Santapa (rise of temperature), Swedavarodha (obstruction to perspiration) and angamarda (pain all over the body) exists simultaneously.4, 5 In Ayurveda, Madhavakara explained dandaka jwara which merely matches with another name of dengue i.e. breakbone fever but symptoms do not match other than severe body ache.5 Charakacharya in nidanastana explained about Pittaja jwara6 which indicate the dengue fever, and pitta Pradhana kaphavaata heena jwara7 explained in chikitsa sthana clearly denote the complication or late stage of dengue i.e, dengue hemorrhagic fever and dengue shock syndrome. Hence pittaja jwara and pitta Pradhana kaphavaata heena jwar are the stages in dengue fever ORIGIN OF THE RESEARCH PROBLEM: Amid climate change, vector borne diseases are spreading at increased rates across larger areas, Dengue is the most rapidly spreading mosquito born viral illness. Dengue, the sometimes fatal, painful viral infection has been spiking in many parts of India in recent years with the West Bengal, Kerala, Karnataka, and Maharashtra particularly hard hit. In 2023, India officially recorded 289235 cases and 485 deaths. In 2024, 19447 cases reported and 16 deaths till 21st February 20241 From 2005 to 2024 many research works were done on Dengue in Ayurveda but remarkably many researches are carried after 2019, post COVID-19. Many of researches were focusing mainly Platelet count fall and immune boost. Even case studies were done on Dengue with drugs like Tulsi, Amruta, Amalaki, and Triphala but studies to aim Dengue fever and to prevent its complication Dengue hemorrhagic fever not conducted with large sample size. The preparation Hriberadi Paneeya8 has Musta, Parpataka, Ushira, Chandana, and Hribera, all these drugs have tikta rasa and sheeta veerya which help to treat Jwara at the same time will help to prevent complications of Dengue. DEFINITION OF THE RESEARCH PROBLEM: This research study emphasizes providing an adjuvant therapy through Ayurveda to manage Dengue Fever and prevent its complications. The classical herbal formulation ‘Hriberadi Paneeya’ has not been evaluated in any research studies for its effectiveness in Dengue and can provide a better option for management. RESEARCH GAP/REVIEW OF LITERATURE: Charakacharya in nidanastana explained about Pittaja jwara6 which indicate the dengue fever, and Pitta Pradhana kaphavaata heena jwara7 explained in chikitsa sthana clearly denote the complication or late stage of dengue i.e, dengue hemorrhagic fever and dengue shock syndrome. Hence pittaja jwara and pitta Pradhana kaphavaata heena jwar are the stages in dengue fever.
In Ayurveda very few studies are conducted on Dengue fever and most of them are focusing on platelet count with the intervention of Eranda karkati (carica papaya) patra swarasa. No study focused on preventing the complications. The Hriberadi Paneeya mentioned in Charaka Samhita Chikitsa sthana, no studies are conducted which helps in treating Dengue fever and preventing its complications as well. METHODOLOGY Study design - An Open - Label Randomized Controlled Clinical Trial Sample source - 1) Shri Hingulambika Education Society’s Ayurvedic Medical College and Hospital, Kalaburagi, Karnataka. 2) Sujani Mother and Child Care Hospital, Kalaburagi, Karnataka Sample size - 40 patient in each group (Mann Whitney U Test is used to calculate the sample size) GROUPING AND RESEARCH DESIGN | Groups and sample size | Intervention | | A (50) | Contemporary medical management | | B (50) | Contemporary medical management except IV fluids along with Hriberadi paneeya as adjuvant therapy | DURATION: The clinical trial will last for 7 days FOLLOW UP: After 7 days (14th day) DELIVERABLES / OUTCOMES: Dengue patients with Hriberadi paneeya recover fast Dengue patients with Hriberadi paneeya will not have recrudescence Dengue patients with Hriberadi paneeya will not progress to complication (DHF, DSS) REFERENCES: 1)https://www.indiatoday.in/health/story/how-rising-dengue-burden-is-costing-india-and-sri-lanka-billions-2516716-2024-03-19 2) https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON518 3)https://ncvbdc.mohfw.gov.in/index4.php?lang=1&level=0&linkid=431&lid=3715 4)https://m.economictimes.com/magazines/panache/dengue-risk-re-evaluated-india-research-finds-first-infections-can-be-as-severe-as-secondary/articleshow/108384055.cms 5)Sharma A, jain A, jain bhadora S. Kayachikitsa. Vol. 2. Delhi: Choukhamba orientalia; 2018.p.470 6)Agnivesha, Charaka samhita, Nidanasthana Chapter 1st, Shloka 16. Gangasahaya Pandeya editor, 8th ed. Varanasi: Chaukhambha Bharati Academy; Reprint2004.p.473. 7)Agnivesha, Charaka samhita, Chikitsasthana, Chapter 3, Shloka 4. DR.Bramhanand TRipathi editor. Varanasi: Chaukhambha Sanskrit Sansthan; 4th edition; 1994. p.112. 8)Agnivesha, Charaka samhita, Chikitsasthana, Chapter 4, Shloka 31. Dr.Brahmanand Tripathi editor. Varanasi: Chaukhambha Sanskrit Sansthan; 4th edition; 1994. p. 226. |