FULL DETAILS (Read-only)  -> Click Here to Create PDF for Current Dataset of Trial
CTRI Number  CTRI/2025/01/078927 [Registered on: 17/01/2025] Trial Registered Prospectively
Last Modified On: 11/05/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Single Arm Study 
Public Title of Study   To study the efficacy of Mulethi Churna in Raktashaya and Jatharagni. 
Scientific Title of Study   An Evaluation of efficacy of Mulethi Churna in Raktakshaya and Jatharagni w.s.r. to "Raktakshaye mandah sanjayte analah". 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  DR FIROJ KUMAR 
Designation  PG SCHOLAR 
Affiliation  Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 
Address  Department of Kriya Sharir Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 India

Raipur
CHHATTISGARH
492010
India 
Phone  8103966622  
Fax    
Email  fkhandey@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Gitanjali Sasmal  
Designation  HEAD OF DEPARTMENT  
Affiliation  Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 
Address  Department of Kriya Sharir Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 India

Raipur
CHHATTISGARH
492010
India 
Phone  9407772981  
Fax    
Email  drgsasmal@rediffmail.com  
 
Details of Contact Person
Public Query
 
Name  DR FIROJ KUMAR 
Designation  MD Scholar  
Affiliation  Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 
Address  Department of Kriya Sharir Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 India

Raipur
CHHATTISGARH
492010
India 
Phone  8103966622  
Fax    
Email  fkhandey@gmail.com  
 
Source of Monetary or Material Support  
Department of Kriya Sharir Shri Narayan Prasad Awasthi Government Ayurved college Raipur Chhattisgarh 492010 India 
 
Primary Sponsor  
Name  Department of Kriya Sharir Shri NPA Govt Ayurved college Raipur Chhattisgarh 492010 
Address  DEPARTMENT OF KRIYA SHARIR SHRI NARAYAN PRASAD AWASTHI GOVT AYURVED COLLEGE RAIPUR CHHATTISGARH 492010 India  
Type of Sponsor  Other [Government Ayurved College ] 
 
Details of Secondary Sponsor  
Name  Address 
Nil  Nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Firoj kumar  Shri khudadad Dungaji Government Ayurved Hospital Raipur 492010 Chhattisgarh India  Speciality clinic 1 and 2
Raipur
CHHATTISGARH 
8103966622

fkhandey@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Office of the Principal, Shri Narayan Prasad Awasthi Government Ayurved college Raipur Chhattisgarh 492010Institutional Ethics Committee   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:D50-D53||Nutritional anemias. Ayurveda Condition: RAKTAKSHAYAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmDrugClassical(1) Medicine Name: Mulethi , Reference: Sushruta Chikitsasthana 44 shlok number 23, Route: Oral, Dosage Form: Churna/ Powder, Dose: 3(g), Frequency: bd, Bhaishajya Kal: Adhobhakta, Duration: 2 Months, anupAna/sahapAna: Yes(details: Madhu), Additional Information: -
 
Inclusion Criteria  
Age From  15.00 Year(s)
Age To  49.00 Year(s)
Gender  Both 
Details  (1) Patients with age group 15 to 49 years.

(2) Patients irrespective of gender, marital status , socio-economics status, religion, occupation etc.

(3) Patients having haemoglobin range 7-10 gm% in female and 9-13% in male.

(4) Patients of nutritional deficiency Anaemia only.

(5) Patients who agree to sign consent form .


 
 
ExclusionCriteria 
Details  1. Patient with age below 15 years and above 49 years.
2. Patient having Haemoglobin range less than 7gm% and more than 10 gm% in female less than 9gm% and more than 13 gm% in male
3. Pregnant and lactating women.
4. Any haemorrhagic condition.
5. Patients suffering from any systemic disease like renal, thyroid disorders etc.
6. Patient suffering from haematological disorders such sickle cell anaemia and thalassemia.
7. Patient suffering from Aplastic anaemia & haemolytic anaemia.
8. Patient not giving consent. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
Oral administration of mulethi churna will lead to an improvement in Raktakshaya.  2 months 
 
Secondary Outcome  
Outcome  TimePoints 
Consumption of Mulethi Churna will lead to an improvement in Jatharagni   2 months 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "37"
Final Enrollment numbers achieved (India)="37" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   03/02/2025 
Date of Study Completion (India) 23/04/2026 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) 23/04/2026 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Maintenance of health of healthy person is the primary aim of the Ayurvedic classics as mentioned in
Charaka Samhita. Arogya is dependend on Doshasamyata, Dhatu Samyata, Agni Samyata and Samyag
Malakriya. Aarogya is characterised by free from any Elements excellence of voice and complersion,
proper metabolism, high physical, and mental strength, desired for food with appeteting in proper time
and proper digestion, appropriate sleep without any dream, proper empulsion of flatus, urine, stool and
semen excellence in motor and sensory perception.
On giving importance to Jatharagni Acharya Charak has mentioned its povital role in maintaining
health and longevity. Sustaining of life is depends on Jatharagni as the cessation of Agni leads to the
death of an individual.
Acharya Sushruta’s perspective underscores the close relationship between Pitta and Agni in Ayurveda.
He suggests that Pitta, one of the three doshas, is intimately linked to the concept of Agni within the
body.
Ayurveda categorizes Agni into three major types based on their locations and substrates they act upon:
Raktagni, a subtype of Dhatvagni (tissue metabolism), is responsible for the digestion and metabolism
of Rakta dhatu. Ranjak Pitta works in conjunction with Raktagni, simultaneously aiding in the
formation and maintenance of Rakta Dhatu.This collaboration between Raktagni and Ranjak Pitta
highlights the intricate interplay between digestive fire (jatharagni) and the formation of blood tissue
(Rakta Dhatu) in Ayurveda.So in depletion of Rakta Dhatu, known as Raktakshaya, lead to Mandagni,
or low digestive fire.
Raktakshaya symptoms according to Acharya Charak are Parusha, Sfutita, Mlana, Twagruksha, Rakta
Sankshaye and according to Acharya Sushruta are Shonita Kshaye, Twak Parushya, Amla
Shitaprarthna, Sirasaithilya.
Raktkshaya co-related with the anaemia, particularly nutritional deficiency anaemia, where the
haemoglobin level in the blood is diminished from normal.
Mulethi possesses the qualities like Madhura in rasa and Vipak, guru, Snigdha in Guna, Seeta in
Virya8& Sonitasthapak.
According to old researches, a lot of work has been done related to Rakta Dhatu and it’s Kshaya
(Raktalpata). The critical need for research to show how Rakta Dhatu Kshaya affects the digestive
power or jatharagni. It is important to study as various diseases are originated from Mandagni. In India
Raktadhatu Kshaya or anaemic patient seen more and more. According to the national family health
survey (NFHS – 5) about 40 % of women & 18.9% of men are moderately anaemic, 1% of both are
severely anaemic. Prevalence of anaemia in India rural areas (women 58.5%, men 27.4%) is highly than
urban areas (women 53.8%, men 20.4%)10, Prevalence of Anaemia in Chhattisgarh rural areas (women
62.2%, men 28.9%) and urban areas (women 56.5%, men 22.5%)10. Most of the anaemia are due to
inadequate supply of nutrients like iron, folic acid and vitamin B12, A, C, etc. Most cases of anaemia
are linked to deficiencies in essential nutrients like iron, folic acid, amino acids, and various vitamins.
It suggests that Rakta Dhatu Kshaya can be prevented through proper nutrition and adherence to the
principles of Pathya Ahara-Vihara, as prescribed in Ayurveda.
Mulethi is Madhu in Rasa, Guru, Snigdha in Guna, Madhur in Vipaka, Sheet Virya and Shonita Sthapak
it can be increases blood and Jatharagni simultaneously. So I choose this topic to establish the relation
of Rakta dhatu and Jatharagni.
 
Close