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CTRI Number  CTRI/2025/01/079485 [Registered on: 27/01/2025] Trial Registered Prospectively
Last Modified On: 24/01/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Effect of Proprioceptive Neuromuscular Facilitation on Functional Outcomes in Office Workers Diagnosed with Upper Cross Syndrome 
Scientific Title of Study   Effect of Proprioceptive neuromuscular facilitation on upper cross syndrome in office workers 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Surbhi 
Designation  Associate Professor 
Affiliation  Galgotias University 
Address  Room Number-B 316, Galgotias University, Plot No-2, Yamuna Expressway, opposite Buddha International Circuit, Sector 17A, Greater Noida, Uttar Pradesh. 203201

Gautam Buddha Nagar
UTTAR PRADESH
201203
India 
Phone  8527389589  
Fax    
Email  surbhi.kaura@galgotiasuniversity.edu.in  
 
Details of Contact Person
Scientific Query
 
Name  Md Samiullah 
Designation  student 
Affiliation  Galgotias University 
Address  Room number- E-003,Galgotias University, Plot No-2, Yamuna Expressway, opposite Buddha International Circuit, Sector 17A, Greater Noida, Uttar Pradesh. 203201

Gautam Buddha Nagar
UTTAR PRADESH
203201
India 
Phone  06200985552  
Fax    
Email  mdsamiullah966@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Md Samiullah 
Designation  student 
Affiliation  Galgotias University 
Address  Room no E003, Galgotias University, Plot No-2, Yamuna Expressway, opposite Buddha International Circuit, Sector 17A, Greater Noida, Uttar Pradesh. 203201

Gautam Buddha Nagar
UTTAR PRADESH
Dr Surbhi Kaura
India 
Phone  06200985552  
Fax    
Email  mdsamiullah966@gmail.com  
 
Source of Monetary or Material Support  
Galgotias University, Opposite Buddha International Circuit, Gautam Buddha Nagar, Uttar Pradesh, 203201, India 
 
Primary Sponsor  
Name  Galgotias University 
Address  E003 lab OPD physiotherapy Galgotias University plot 2 sector 17A Yamuna expressway Greater noida Gautam Budh Nagar 
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Neeraj Sharma  Galgotias University  Room number- E003, Galgotias University, Plot No-2, Yamuna Expressway, opposite Buddha International Circuit, Sector 17A, Greater Noida, Uttar Pradesh. 203201
Gautam Buddha Nagar
UTTAR PRADESH 
6200985552

md.21smas1010051@galgotiasuniversity.edu.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Departmental Research Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  upper cross syndrome cervical pain 
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Control group  warmup aerobic exercise 3times per week 45 minutes for 6 weeks static light stretching postural exercise 
Intervention  PNF intervention group  3 times per week for 45 minutes for 6 weeks aerobic exercise warmup PNF stretching target muscle pectoralis Functional training coold off home based postural exercise 
 
Inclusion Criteria  
Age From  25.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  Office worker aged 25-50years.
Individual who spends at least 6 hours a day in a sedentary position, primarily working at a desk or computer.
Participants must have experienced symptoms of UCS, such as neck pain, shoulder tightness, or postural imbalances, for at least 3 months.
 
 
ExclusionCriteria 
Details  Patient excluded with condition such as cervical disc herniation, severe scoliosis or neurological disorders.
Patient who undergoes surgery or injury related to neck, shoulder or upper back are excluded.
Patient with medical condition or physical limitation are excluded. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   On-site computer system 
Blinding/Masking   Participant and Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
NRS pain scale, MMT for muscle strength, FMS and quality of life SF36  baseline and 6 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
Quality of LifeShort Form Health Survey SF-36
 
baseline and 6 weeks 
 
Target Sample Size   Total Sample Size="68"
Sample Size from India="68" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 3 
Date of First Enrollment (India)   09/02/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  09/02/2025 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="8"
Days="0" 
Recruitment Status of Trial (Global)   Open to Recruitment 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   The first person to introduce the term Upper Cross Syndrome was Dr. Vladimir Janda. It describes an imbalance between the muscles of the neck, shoulders and chest which is very common in modern society(1). Nowadays people spend more time sitting than ever before, especially office workers--with their higher educational levels and white-collar status. They typically sit at desks for an extended period of time, chipping away at their brains with work routines that are both monotonous and repetitive. With this type of work posture ever maintained on a long-term basis, the muscles and skeleton bear a definite mark. This is known as Upper Cross Syndrome--muscle tightness and weakness characterizing the syndrome, postural habits, and movement stereotypes(2).
People with UCS frequently suffer from tightness in the muscles of the upper trapezius, levator scapulae, pectoralis major and minor. This is associated with weakness in the deep cervical flexors, lower trapezius and serratus anterior(3). The negative effects of this imbalance lead to a flexed posture of the upper cervical spine, overdevelopment of the accessory muscles, and an abnormal posterior cervical curve. As a result, people with these changes have neck pain, shoulder dysfunction (e.g., scapular winging), and headaches accompanied by reduced functional capacity or work output--disabling syndromes that greatly affect an individual’s quality of life(4).
As for office workers, they are doubly liable to develop UCS. They are engaged in work that is sedentary and computer-based; they often sit for very prolonged periods. With the extra complications of a possible slouching weight against them on a hard desk or against their thighs (in their laps) or even more significantly, motorcycle saddles and low ergonomic setups at best, is modern electronic technology (for instance smartphones and laptops)urging peoples’ bodies introduce further distortion into this pattern: forward head carriage(5). In other words, it makes individuals round their shoulders, crane necks and stoop over computers which leaves the thoracic spine heavily kyphotic. Office workers tend to suffer from sore backs, strained shoulders and stiff necks due largely then to the idiomatic distortions in lifestyle that accompany their occupation. 
Proprioceptive Neuromuscular Facilitation (PNF) is a therapeutic approach that has been used extensively in the rehabilitation of a variety of different musculoskeletal and neurological conditions(6). PNF techniques are designed to increase the strength and flexibility of muscles, improve motor control, and facilitate the body’s neuromuscular response to sensory input. The basic principles of PNF require the use of proprioceptive inputs to excite and pattern out functional movement for the neuromuscular system. PNF techniques often combine stretching, resisted movement, and the use of diagonal and spiral patterns to get muscle groups to work in a way that promotes natural movement(7).
The application of PNF in treating Upper Cross Syndrome is of particular interest because it deals with both aspects of the condition’s double bind muscle tightness and muscle weakness. Traditional treatments for managing UCS usually focus on isolated stretching of the muscles and strengthening the weakened ones. However, PNF takes a more global approach by integrating neuromuscular coordination between agonist and antagonist muscles, with potential implications for a cure that is more effective over time for postural imbalances associated with UCS.
Research on the use of PNF for correcting problems like UCS is still in its early days, but preliminary evidence indicates that it can be an effective modality in improving posture, decreasing pain, and increasing the functional capacity of those with musculoskeletal imbalances. The potential advantages derived from PNF are a heightened awareness of proprioceptor activity, better posture, enhanced muscle strength, and increased flexibility in connective tissue and muscle fibers, all things that are essential to managing the symptoms of UCS.
 
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