In present time, due to modern lifestyle, hectic schedule, stress, and many such reasons, incidence of diseases are increasing, one of them is Amavata. The concept of autoimmunity is well explained under the concept of Ama, an intermediate product generated due to the deranged metabolism of the digestive fire triggering the chronic inflammatory process in the body.

Rheumatoid arthritis is a chronic inflammatory disease. In the whole world, rheumatic disease is the most common cause of physical impairment in society. The lives of more than one million people are physically impaired by rheumatic disorders and one fifth of them are severely disabled. The prevalence rate of this disease is about 3%, with male female ratio of 1:3. It occurs throughout the world in all climates and ethnic groups.

Madhavakara was the first person to give a detailed description of Amavata. It effects the individuals, who indulge in viruddhahara (improper and irregular dietary habits) viruddha chesta (improper physical and psychological activities) sedentary habits and people who exercise immediately after intake of unctuous food.

The word "Ama" literally means undigested, toxic or unwholesome product, which is produced in the body due to the weakening of digestive fire. This ama is then carried by vitiated vayu and travel throughout the body and gets accumulated in the joints, which is seat of kapha. As this process continues in all joints, it results in severe pain and swelling in the joints. Here pain is due to vitiated vata and swelling is due to vitiated kapha. When pitta also get aggravated, it causes burning sensation in the joints.

Amavata may be correlated with Rheumatoid arthritis, it is a chronic progressive autoimmune arthropathy characterised by bilateral symmetrical involvement of joints with systemic clinical manifestations. It is basically Sero Positive RA & Sero Negative RA. (In Blood RA factor Positive, and Negative)