1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response - None of the above
   
   
3. Who will be able to view these files?
   Response - Anyone
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [SWATIY0102@GMAIL.COM].
   


6. For how long will this data be available start date provided 10-10-2024 and end date provided 10-10-2060?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Catheter-related bloodstream infection (CRBSI) is defined as the presence of bacteremia originating from central venous catheter. It is one of the most frequent, lethal, and costly complications of central venous catheterization and also the most common cause of nosocomial bacteremia. Intravascular catheters are integral to the modern practices and are inserted in critically-ill patients for the administration of fluids, blood products, medication, nutritional solutions, and for hemodynamic monitoring. Central venous catheters (CVCs) pose a greater risk of device-related infections than any other types of medical device and are major causes of morbidity and mortality.

The definitive diagnosis of catheter infection can be made by using a combination of clinical signs and symptoms together with the various culture techniques. Patients with CVC catheters developing fever or chills, unexplained hypotension, and no other localizing sign suggest possibility of CRBSI. Catheter site infection is indicated by the presence of erythema, swelling, tenderness, and purulent drainage around the catheter exit and the part of the tunnel external to the cuff. Risk factors for CRBSI include immunocompromised status, neutropenia Burns, Malnutrition, BMI >40, Prolonged hospitalization before catheter insertion, emergency catheter insertion, incomplete adherence to aseptic technique, multiple manipulations of the catheter, failure to remove unnecessary catheter. The administration of parenteral nutrition through intravascular catheters increases CRBSI risk. Local risk factors, such as poor personal hygiene, occlusive transparent dressing, moisture around the exit site, S. aureus nasal colonization, and contiguous infections support the role of bacterial colonization in the pathogenesis of CRBSI.