A prospective study to compare the efficacy of two different doses of intramuscular dexmedetomidine in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation.

Aim:

To compare the efficacy of two different doses of intramuscular Dexmedetomidine on attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia.

Objective:

To compare the efficacy in attenuating heart rate during laryngoscopy and endotracheal intubation.

To compare the efficacy in attenuating blood pressure (systolic blood pressure, diastolic blood pressure and mean arterial pressure) during laryngoscopy and endotracheal intubation.

To compare post operative sedation between the study groups by RAMSAY Sedation Score.

Group A: patients will receive inj. Dexmedetomidine 1mcg/kg intramuscularly 60 minutes prior to induction of anesthesia.

Group B patients will receive inj. Dexmedetomidine 1.5mcg/kg intramuscularly 60 minutes prior to induction of anesthesia 

Drug will be administered by the consultant Anesthesiologist present in the operation theatre.

Monitoring of parameters i.e.HR, SBP, DBP, MAP, SPO2 will be noted  at baseline, every 15 mins after i.m injection of test drug till induction, after giving inducing agents, during laryngoscopy and intubation and at 1,3,5 & 7 minutes after intubation.

Post-operatively, sedation status will be assessed half hourly by RAMSAY Sedation Score (RSS) till a score of ≤ 3 is achieved.

Inclusion criteria:

Patients willing to sign informed consent.

Male or female patients between 18 to 60 years of age.

Patients belonging to American Society of Anesthesiologists (ASA) physical status I and II.

Patients posted for elective surgeries under general anaesthesia.

Exclusion criteria:

Patients unwilling to participate in the study.

Patients with Body Mass Index ≥ 30 kg/m².

Patients with history of muscular disorder , myositis , or any local infection

Patients with cardiovascular diseases, arrhythmias, heart blocks, or taking beta blockers.

Patients with cerebrovascular, hepatic and renal diseases.

Psychiatric patients.

Patients with history of allergy to an α-2 adrenergic agonist

Pregnancy & lactating women.

Site of Study: Department of Anaesthesiology, Dhiraj Hospital, S.B.K.S. Medical Institute and Research Centre, Piparia, Waghodia, Vadodara, Gujarat.

Study Design- Prospective, Observational and Comparative Study

Study Duration- The study will be initiated after obtaining the permission from institutional ethics committee for duration of 18 months.

Statistical analysis:

Numerical variables will be presented as mean & standard deviation (SD) while categorical variables will be presented as frequency and percentage. As regard to numerical variables; tests like unpaired student–t test and/or ANNOVA will be used whenever appropriate for between-groups comparisons, while for categorical variables; chi–square test will be used. p value <0.05 will be considered statistically significant.

Likely outcome/ Benefits of the study:

This prospective and observational study will help us to compare the efficacy between two different doses of intramuscular Dexmedetomidine in attenuating hemodynamic responses to laryngoscopy and endotracheal intubation in patients undergoing surgeries under general anaesthesia and will enable us to know which dose of the dexmedetomidine drug is most beneficial in giving balanced general anaesthesia by having better outcomes in hemodynamics.