1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response (Others) -  By email to contact person


6. For how long will this data be available start date provided 31-12-2026 and end date provided 31-12-2029?
   Response - Beginning 9 months and ending 36 months following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

·     Oral submucous fibrosis (OSMF) is a chronic, inflammatory, and potentially malignant disorder of the oral cavity, and has been linked to the chewing of areca nut. Oral submucous fibrosis has a number of characteristic signs and symptoms, including gradual mouth narrowing, oral mucosal blanching, burning and discomfort while consuming food, hypomobility of the tongue and soft palate, diminished taste sensibility, and minor hearing impairment as a result of eustachian tube obstruction.

       Polyphenols have antioxidant properties that make them important for both preventing and treating OSMF. Turmeric, an Indian golden spice, is a polyphenol that has long been known for its medicinal effects. From ancient times, curcumin, the active ingredient in turmeric, has been utilized extensively in India as a folk medicine for many diseases.It is used as an anti-inflammatory, antibacterial, antioxidant, anticancer agent towards treatment of inflammatory, immune mediated and potentially malignant lesions.

·    Clove (Syzygium aromaticum) is one of the most valuable spices that has been used for centuries as food preservative and for many medicinal purposes plant represents one of the richest sources of phenolic compounds such as eugenol, eugenol acetate and gallic acid and possess great potential for pharmaceutical, cosmetic and food applications. The spice contains a good amount of minerals like magnesium, manganese, potassium, iron, and selenium Antioxidants are compounds which are essential for the treatment of oxidative stress. Treatment with clove oil reduces oxidative stress mediated by reduced glutathione levels. 

Clove oil and turmeric may provide a powerful combination for management of oxidative stress in OSMF and for improving its signs and symptoms. It may be a potential breakthrough in management of OSMF using indigenous, herbal products.