Stress, a significant psychosocial stressor, is a primary contributor to the pathogenesis of various mental health disorders, including anxiety and depression. Its deleterious effects extends beyond emotional distress, impairing cognitive function, such as concentration and decision-making. The intricate relationship between stress, mental health, and cognitive function underscores the necessity for effective stress management strategies to mitigate these detrimental consequences and promote overall well-being. Moreover, the potential interplay between stress, nutrition, and cognitive health necessitates a comprehensive approach to address these interconnected factors. The prevalence of stress and anxiety has significantly increased in recent years, with approximately one-third of the population reporting symptoms. Mood and anxiety disorders, encompassing stress, anxiety, and depression, constitute a significant public health burden . Systematic reviews of longitudinal and cross-sectional data consistently demonstrate an inverse relationship between stress and quality of life. Additionally, research indicates that chronic psychological stress may accelerate the aging process. Pharmacological interventions are indicated for severe mental health conditions, while milder presentations often benefit from a multimodal approach integrating nutraceuticals and cognitive-behavioral therapy (CBT). This holistic strategy optimizes outcomes while mitigating the economic burden associated with psychotropic medications and overcome significant barriers to care.

Individuals with mental health diagnoses often encounter significant stigma and social discrimination, leading to reduced help-seeking behaviours. This manifests in avoidance of healthcare settings and limited engagement with mental health professionals, hindering therapeutic alliance and information disclosure. Non-adherence to prescribed psychotropic medications, particularly within public and academic environments, is a prevalent challenge. These factors underscore the urgent need for innovative therapeutic strategies to address the multifaceted barriers to mental health care. The convenience and established efficacy of traditional tablet formulations offer distinct advantages for medication adherence. Tablets provide a reliable and consistent method of drug delivery, contributing to optimal therapeutic outcomes. Mentacalm tablet containing ingredients which have the potential to calm the mind, reduce brain hyperactivity, and improve mood and anxiety. Within this compendium of noteworthy botanical agents, Bacopa monnieri and Convolvulus prostrates stands out as an herb with an extensive historical tradition and a multitude of purported health benefits, in the investigational product along with Withania somnifera, Celastrus paniculatus, Acorus calamus, Terminalia arjuna, Valeriana wallichii it could synergistically add potential to mitigate stress and related symptoms in a better way. While these ingredients show promise in preliminary research, further studies are needed to confirm their effectiveness at the dosages typically found in tablets. The current research aims at evaluating safety and efficacy of Mentacalm in management of stress and anxiety in adults.