Background: The use of tobacco is prevalent in all age groups throughout the world. In India, its use is culturally accepted in most parts of the country, and as such, it is also easily available. As per the Global Adult Tobacco Survey 2 (GATS 2) fact sheet for Assam (2016–17), the prevalence of smokeless tobacco use has increased significantly (i.e., 41.7%) from GATS 1 by 9 percentage points. Many studies have been conducted on smoking tobacco, but only a handful of interventional research studies are available on the use of smokeless tobacco in India, especially in the NE region. The aim of the study is to assess the efficacy of the Brief Intervention (BI) module for smokeless tobacco users in a selected villages of Sonitpur district, Assam. Methodology: The researcher will adopt a randomized controlled trial research design. Setting will be selected villages of Sonitpur district of Assam, and population will be smokeless tobacco (SLT) users. In the first phase of the study the content of the brief intervention module will be prepared based on the existing models and will be validated from experts in different related fields. Then in the second phase of the study, three randomly selected villages under Bihaguri PHC will be visited and houses will be selected randomly by using random number table. A total of 86 samples will be included in the study as per inclusion and exclusion criteria and by using lottery method randomization will be done to allocate samples in experimental and waitlist control group. Three visits will be done to the houses at one month interval. On the first day socio-demographic information will be collected from selected participants by using a socio-demographic proforma and pretest will be conducted for both experimental and waitlist control group by using the Fragerstrom Nicotine Dependence Scale (FTND), the Fragerstrom Nicotine Dependence-Smoking Tobacco (FTND-ST) Scale, The Alcohol, Smoking and Substance Involvement Screening Test V3.0 (ASSIST-V3.0), the University Rhode Island Change Assessment Scale (URICA), and semi-structured questionnaires to assess abstinence period, perception, and awareness regarding smokeless tobacco use. On the same day Brief Intervention will be provided only to the experimental group by using validated Brief Intervention Module. 2^nd visit will be done at one month after 1^st visit and posttest will be conducted for both the groups. On that day, after post test brief intervention will be provided to the waitlist control group. On the third visit booster session will be conducted for experimental group and posttest will be done for waitlist control group. After the required number of participants have provided their data, all of the data will be gathered and statistically examined by using descriptive and inferential statistics.