Childhood period witness maximum physical and psychological growth and development, hence ensuring the same against certain infections, nutritional, environmental and auto immune disorders is need of the hour as it adversely affects the future life of child. Healthy childhood period is a platform for future healthy life.

Principles of Ayurveda are very unique due to its global approach with utmost importance to prevent the disorders rather than curing the disease. As the generation passed the human lifestyle has been deviated from normal principles of nature, resulting in numerous immunological and life style related disorders which are becoming very common in present day scenario.

 As per evidences the immunodeficiency, immuno suppressive and hyper immunity disorders are three major categories of immune disorders in children in recent days. Incidences of hyper immunity or immune exaggeration are on the upper surge in past few decades and emerged as burning problem in the present-day clinical practice and minimal change nephrotic syndrome is one among them, which is becoming more and more common in early pediatric age.

Minimal change nephrotic syndrome is one of the common types of primary nephrotic syndrome (90%). The incidence of Nephrotic Syndrome (MCNS) is 2-7 patients in 100000 population per year and is equally found in both sexes, as per ISKDC (International Study of Kidney Diseases in Children)[i]. In India childhood nephrotic syndrome has an incidence of 90-100 per million population[ii]. It is characterized by symptom complex which include proteinurea, hypoalbuminemia and edema. The characteristic symptoms are heavy/ massive proteinurea (>3.5 gm /24 hrs in adults or 40mg/m2/hr in children), hypoalbuminemia (<2.9gm/dl), edema, hyperlipidemia(220mg/dl) with increased tendency for coagulation[iii]. According to International Study of Kidney Diseases in Children (ISKDC classification), this is an immunological disorder with affliction of glomeruli due to deposition of the immune complex leading to basement membrane and podocyte layer damage which further leads to increased albumin loss through glomerullar filtration. In the later part there will be hyalization and also loss of other constituents of the blood including RBC.

In Minimal Change Nephrotic Syndrome, Renal biopsy does not show significant abnormalities in light microscopy. On the other hand, Focal Segmental glomerulonecrosis (FSGS) the other type of primary nephrotic syndrome shows evidence of sclerosis involving a segment of glomerular tuft.

Minimal change nephrotic syndrome is known for its recurrency and relapse, especially after a viral infection due to immune exaggeration and with each recurrency disease become more and more chronic[iv]. This not only hampers the growth of the body but also functional capacity of child leading to psychological instability along with behavior and personality changes. School missing may lead to failure in academic performances. However, as the disease becomes chronic the complications of the disease and adverse effect of the medication totally debilitate the child.

The series of complications of Nephrotic syndrome are like infections, thromboembolic disorders, acute kidney failure, pulmonary edema, protein malnutrition and growth retardation. Meanwhile continuous loss of protein, especially albumin through urine resulting in altered plasma oncotic pressure and leads to disturbance in fluid compartment and leads to progressive edema which is more evident in the periorbital area. Later edema spreads to dependent area, peritoneum, pleura and pericardium.

However, Ayurveda understand above disease entity with immunological background and this can be included under different complications and sequels of Ojo Vyapada which includes symptom complex like   Vaata Shopha, Stambdhagaatrataa, varnabheda, guru gaatrataa, glaani, tandra, nidra.[v] etc.